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Relationship between Investigative Biomarkers and Radiographic Grading in Patients with Knee Osteoarthritis
المؤلفون المشاركون
Sánchez, Mikel
Zalduendo, Mar
Andía, Isabel
Anitua-Aldecoa, Eduardo
Azofra, Juan
de la Fuente, Maria
Aguirre, Jose J.
المصدر
International Journal of Rheumatology
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-04-06
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Objective.
To examine new investigative biomarkers and their relevance for radiographic severity in knee osteoarthritis.
Methods.
The group comprised 63 patients with 73 knees examined.
Patients were divided according to radiographic severity to allow for comparison of biomarker levels.
Hyaluronic acid (HA), matrix metalloproteases (MMP-1, MMP-3 and MMP-13), tissue inhibitors of metalloproteases (TIMP-1 and TIMP-2), platelet-derived growth factor (PDGF-AB), transformed growth factor (TGF-β), vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF) and insulin-like growth factor (IGF-I) were measured on synovial fluid and in plasma releasate at a single time point.
Principal component analysis (PCA) followed by analysis of covariance were applied to evaluate data.
Results.
Four different groups of biomarker were identified in plasma releasates.
The first (platelet number, PDGF-AB and TGF-β) and second groups (HA and IGF-I) were related to radiographic severity, P=.005 and P=.022, respectively.
The third (MMP-1 and TIMP-2) and fourth groups (MMP-3 and TIMP-1) represented the catabolic balance, but were not associated to radiographic grading.
Three different clusters of biomarkers were found in synovial fluid but did not show any significant association to radiographic grading.
Conclusions.
New imaging approaches to assess structural deterioration and correlation with biomarker levels are warranted to advance in OA research.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Anitua-Aldecoa, Eduardo& Sánchez, Mikel& de la Fuente, Maria& Azofra, Juan& Zalduendo, Mar& Aguirre, Jose J.…[et al.]. 2009. Relationship between Investigative Biomarkers and Radiographic Grading in Patients with Knee Osteoarthritis. International Journal of Rheumatology،Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-495495
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Anitua-Aldecoa, Eduardo…[et al.]. Relationship between Investigative Biomarkers and Radiographic Grading in Patients with Knee Osteoarthritis. International Journal of Rheumatology No. 2009 (2009), pp.1-4.
https://search.emarefa.net/detail/BIM-495495
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Anitua-Aldecoa, Eduardo& Sánchez, Mikel& de la Fuente, Maria& Azofra, Juan& Zalduendo, Mar& Aguirre, Jose J.…[et al.]. Relationship between Investigative Biomarkers and Radiographic Grading in Patients with Knee Osteoarthritis. International Journal of Rheumatology. 2009. Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-495495
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495495
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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