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Relationship between Investigative Biomarkers and Radiographic Grading in Patients with Knee Osteoarthritis
Joint Authors
Sánchez, Mikel
Zalduendo, Mar
Andía, Isabel
Anitua-Aldecoa, Eduardo
Azofra, Juan
de la Fuente, Maria
Aguirre, Jose J.
Source
International Journal of Rheumatology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-06
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Objective.
To examine new investigative biomarkers and their relevance for radiographic severity in knee osteoarthritis.
Methods.
The group comprised 63 patients with 73 knees examined.
Patients were divided according to radiographic severity to allow for comparison of biomarker levels.
Hyaluronic acid (HA), matrix metalloproteases (MMP-1, MMP-3 and MMP-13), tissue inhibitors of metalloproteases (TIMP-1 and TIMP-2), platelet-derived growth factor (PDGF-AB), transformed growth factor (TGF-β), vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF) and insulin-like growth factor (IGF-I) were measured on synovial fluid and in plasma releasate at a single time point.
Principal component analysis (PCA) followed by analysis of covariance were applied to evaluate data.
Results.
Four different groups of biomarker were identified in plasma releasates.
The first (platelet number, PDGF-AB and TGF-β) and second groups (HA and IGF-I) were related to radiographic severity, P=.005 and P=.022, respectively.
The third (MMP-1 and TIMP-2) and fourth groups (MMP-3 and TIMP-1) represented the catabolic balance, but were not associated to radiographic grading.
Three different clusters of biomarkers were found in synovial fluid but did not show any significant association to radiographic grading.
Conclusions.
New imaging approaches to assess structural deterioration and correlation with biomarker levels are warranted to advance in OA research.
American Psychological Association (APA)
Anitua-Aldecoa, Eduardo& Sánchez, Mikel& de la Fuente, Maria& Azofra, Juan& Zalduendo, Mar& Aguirre, Jose J.…[et al.]. 2009. Relationship between Investigative Biomarkers and Radiographic Grading in Patients with Knee Osteoarthritis. International Journal of Rheumatology،Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-495495
Modern Language Association (MLA)
Anitua-Aldecoa, Eduardo…[et al.]. Relationship between Investigative Biomarkers and Radiographic Grading in Patients with Knee Osteoarthritis. International Journal of Rheumatology No. 2009 (2009), pp.1-4.
https://search.emarefa.net/detail/BIM-495495
American Medical Association (AMA)
Anitua-Aldecoa, Eduardo& Sánchez, Mikel& de la Fuente, Maria& Azofra, Juan& Zalduendo, Mar& Aguirre, Jose J.…[et al.]. Relationship between Investigative Biomarkers and Radiographic Grading in Patients with Knee Osteoarthritis. International Journal of Rheumatology. 2009. Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-495495
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495495