Oncologic Outcomes of Asian Men with Clinically Localized Prostate Cancer after Extraperitoneal Laparoscopic Radical Prostatectomy : A Single-Institution Experience

الملخص EN

Purpose.

To evaluate the midterm oncologic results of extraperitoneal laparoscopic radical prostatectomy (EPLRP) for Asian men with localized prostate cancer.

Methods.

Between 2004 and 2009, 218 men underwent EPLRP at an Asian tertiary hospital.

The mean preoperative prostate-specific antigen (PSA) was 15.5 ng/ml and mean Gleason score was 6.6.

Stage distributions were cT1a-b in 21 cases, cT1c in 139, cT2 in 48 and cT3 in 10.

Disease recurrence was defined as PSA ≥ 0.2 ng/mL in 2 consecutive measurements or initiation of secondary therapy.

Results.

Postoperative pathological stage was pT2a-b in 33 patients, pT2cN0 in 10, pT3a in 27, pT3b in 36, pT4 in 9 and pN1 in 10.

Positive surgical margins occurred in 14.6% and 48.6% for pT2 and pT3 diseases, respectively (P<.001).

The overall PSA recurrence-free survival at 3 and 5 years was 82.1% and 74.5%.

By the pathological stages, 3-year recurrence-free survival was 92.4% (pT2), 81.1% (pT3a), 62.6% (pT3b-4) and 55.6% (pN1), respectively (P<.001).

Conclusions.

EPLRP is curative even for some locally advanced prostate cancers in a midterm follow-up.

Even at an Asian center of low volume of radical prostatectomy EPLRP still provides oncologic outcomes similar to that of high volume centers.