Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association
المؤلفون المشاركون
Acheampong, Joseph
Huang, Hanxia
Adebamowo, C.
Balogun, Williams
Adeleye, Jokotade
Rotimi, Charles N.
Shriner, Daniel
Zhou, Jie
Agyenim-Boateng, Kofi
Jiang, CongQing
Amoah, Albert
Okafor, Godfrey
Zhang, Zhenjian
Adeyemo, Adebowale
Doumatey, Ayo P.
Fasanmade, Olufemi
Oli, Johnnie
Liu, Guozheng
Bentley, Amy Rebecca
Eghan, Benjamin A.
Johnson, Thomas
Chen, Guanjie
المصدر
International Journal of Nephrology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-02
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Low levels of high-density cholesterol (HDLc) accompany chronic kidney disease, but the association between HDLc and the estimated glomerular filtration rate (eGFR) in the general population is unclear.
We investigated the HDLc-eGFR association in nondiabetic Han Chinese (HC, n=1100), West Africans (WA, n=1497), and African Americans (AA, n=1539).
There were significant differences by ancestry: HDLc was positively associated with eGFR in HC (β=0.13, P<0.0001), but negatively associated among African ancestry populations (WA: −0.19, P<0.0001; AA: −0.09, P=0.02).
These differences were also seen in nationally-representative NHANES data (among European Americans: 0.09, P=0.005; among African Americans −0.14, P=0.03).
To further explore the findings in African ancestry populations, we investigated the role of an African ancestry-specific nephropathy risk variant, rs73885319, in the gene encoding HDL-associated APOL1.
Among AA, an inverse HDLc-eGFR association was observed only with the risk genotype (−0.38 versus 0.001; P=0.03).
This interaction was not seen in WA.
In summary, counter to expectation, an inverse HDLc-eGFR association was observed among those of African ancestry.
Given the APOL1 × HDLc interaction among AA, genetic factors may contribute to this paradoxical association.
Notably, these findings suggest that the unexplained mechanism by which APOL1 affects kidney-disease risk may involve HDLc.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bentley, Amy Rebecca& Doumatey, Ayo P.& Chen, Guanjie& Huang, Hanxia& Zhou, Jie& Shriner, Daniel…[et al.]. 2012. Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-495628
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bentley, Amy Rebecca…[et al.]. Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association. International Journal of Nephrology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-495628
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bentley, Amy Rebecca& Doumatey, Ayo P.& Chen, Guanjie& Huang, Hanxia& Zhou, Jie& Shriner, Daniel…[et al.]. Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-495628
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495628
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر