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Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association
Joint Authors
Acheampong, Joseph
Huang, Hanxia
Adebamowo, C.
Balogun, Williams
Adeleye, Jokotade
Rotimi, Charles N.
Shriner, Daniel
Zhou, Jie
Agyenim-Boateng, Kofi
Jiang, CongQing
Amoah, Albert
Okafor, Godfrey
Zhang, Zhenjian
Adeyemo, Adebowale
Doumatey, Ayo P.
Fasanmade, Olufemi
Oli, Johnnie
Liu, Guozheng
Bentley, Amy Rebecca
Eghan, Benjamin A.
Johnson, Thomas
Chen, Guanjie
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Low levels of high-density cholesterol (HDLc) accompany chronic kidney disease, but the association between HDLc and the estimated glomerular filtration rate (eGFR) in the general population is unclear.
We investigated the HDLc-eGFR association in nondiabetic Han Chinese (HC, n=1100), West Africans (WA, n=1497), and African Americans (AA, n=1539).
There were significant differences by ancestry: HDLc was positively associated with eGFR in HC (β=0.13, P<0.0001), but negatively associated among African ancestry populations (WA: −0.19, P<0.0001; AA: −0.09, P=0.02).
These differences were also seen in nationally-representative NHANES data (among European Americans: 0.09, P=0.005; among African Americans −0.14, P=0.03).
To further explore the findings in African ancestry populations, we investigated the role of an African ancestry-specific nephropathy risk variant, rs73885319, in the gene encoding HDL-associated APOL1.
Among AA, an inverse HDLc-eGFR association was observed only with the risk genotype (−0.38 versus 0.001; P=0.03).
This interaction was not seen in WA.
In summary, counter to expectation, an inverse HDLc-eGFR association was observed among those of African ancestry.
Given the APOL1 × HDLc interaction among AA, genetic factors may contribute to this paradoxical association.
Notably, these findings suggest that the unexplained mechanism by which APOL1 affects kidney-disease risk may involve HDLc.
American Psychological Association (APA)
Bentley, Amy Rebecca& Doumatey, Ayo P.& Chen, Guanjie& Huang, Hanxia& Zhou, Jie& Shriner, Daniel…[et al.]. 2012. Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-495628
Modern Language Association (MLA)
Bentley, Amy Rebecca…[et al.]. Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association. International Journal of Nephrology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-495628
American Medical Association (AMA)
Bentley, Amy Rebecca& Doumatey, Ayo P.& Chen, Guanjie& Huang, Hanxia& Zhou, Jie& Shriner, Daniel…[et al.]. Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-495628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495628