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Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate : Implications into the Role of the Complex in Neurodegenerative Diseases
المؤلفون المشاركون
Lovat, M.
Trofimova, L.
Graf, A.
Dunaeva, T.
Efimova, E.
Groznaya, A.
Maslova, M.
Bunik, V.
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-10-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Decreased activity of the mitochondrial 2-oxoglutarate dehydrogenase complex (OGDHC) in brain accompanies neurodegenerative diseases.
To reveal molecular mechanisms of this association, we treated rats with a specific inhibitor of OGDHC, succinyl phosphonate, or exposed them to hypoxic stress.
In males treated with succinyl phosphonate and in pregnancy-sensitized females experiencing acute hypobaric hypoxia, we revealed upregulation of brain OGDHC (within 24 hours), with the activity increase presumably representing the compensatory response of brain to the OGDHC inhibition.
This up-regulation of brain OGDHC was accompanied by an increase in exploratory activity and a decrease in anxiety of the experimental animals.
Remarkably, the hypoxia-induced elevation of brain OGDHC and most of the associated behavioral changes were abrogated by succinyl phosphonate.
The antagonistic action of hypoxia and succinyl phosphonate demonstrates potential therapeutic significance of the OGDHC regulation by the phosphonate analogs of 2-oxoglutarate.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Trofimova, L.& Lovat, M.& Groznaya, A.& Efimova, E.& Dunaeva, T.& Maslova, M.…[et al.]. 2010. Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate : Implications into the Role of the Complex in Neurodegenerative Diseases. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-495636
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Trofimova, L.…[et al.]. Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate : Implications into the Role of the Complex in Neurodegenerative Diseases. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-495636
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Trofimova, L.& Lovat, M.& Groznaya, A.& Efimova, E.& Dunaeva, T.& Maslova, M.…[et al.]. Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate : Implications into the Role of the Complex in Neurodegenerative Diseases. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-495636
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495636
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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