Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate : Implications into the Role of the Complex in Neurodegenerative Diseases
Joint Authors
Lovat, M.
Trofimova, L.
Graf, A.
Dunaeva, T.
Efimova, E.
Groznaya, A.
Maslova, M.
Bunik, V.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Decreased activity of the mitochondrial 2-oxoglutarate dehydrogenase complex (OGDHC) in brain accompanies neurodegenerative diseases.
To reveal molecular mechanisms of this association, we treated rats with a specific inhibitor of OGDHC, succinyl phosphonate, or exposed them to hypoxic stress.
In males treated with succinyl phosphonate and in pregnancy-sensitized females experiencing acute hypobaric hypoxia, we revealed upregulation of brain OGDHC (within 24 hours), with the activity increase presumably representing the compensatory response of brain to the OGDHC inhibition.
This up-regulation of brain OGDHC was accompanied by an increase in exploratory activity and a decrease in anxiety of the experimental animals.
Remarkably, the hypoxia-induced elevation of brain OGDHC and most of the associated behavioral changes were abrogated by succinyl phosphonate.
The antagonistic action of hypoxia and succinyl phosphonate demonstrates potential therapeutic significance of the OGDHC regulation by the phosphonate analogs of 2-oxoglutarate.
American Psychological Association (APA)
Trofimova, L.& Lovat, M.& Groznaya, A.& Efimova, E.& Dunaeva, T.& Maslova, M.…[et al.]. 2010. Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate : Implications into the Role of the Complex in Neurodegenerative Diseases. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-495636
Modern Language Association (MLA)
Trofimova, L.…[et al.]. Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate : Implications into the Role of the Complex in Neurodegenerative Diseases. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-495636
American Medical Association (AMA)
Trofimova, L.& Lovat, M.& Groznaya, A.& Efimova, E.& Dunaeva, T.& Maslova, M.…[et al.]. Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate : Implications into the Role of the Complex in Neurodegenerative Diseases. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-495636
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495636