Hepatic Expression of Metallothionein III, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis
المؤلفون المشاركون
Grubić-Kezele, Tanja
Blagojević Zagorac, Gordana
Jakovac, Hrvoje
Radošević-Stašić, Biserka
Domitrović, Robert
Milin, Čedomila
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
In a search of peripheral factors that could be responsible for the discrepancy in susceptibility to EAE in Albino Oxford (AO) and Dark Agouti (DA) rats, we estimated the expression of metallothioneins I/II (MT), heat shock protein-gp96, interleukin (IL)-6, and transforming growth factor (TGF)-β in the livers of these animals.
Rats were immunized with bovine brain homogenate (BBH) emulsified in complete Freund adjuvant (CFA) or only with CFA.
Western blot and immunohistochemical analyses were done on day 12 after the immunization, as well as in intact rats.
The data have shown that during the first attack of EAE only the EAE prone-DA rats markedly upregulated the hepatic MTs, gp96, IL-6, and TGF-β.
In contrast, AO rats had a significantly higher expression of MT I/II, IL-6, and TGF-β in intact liver (P<0,001), suggesting that the greater constitutive expression of these proteins contributed to the resistance of EAE.
Besides, since previously we found that AO rats reacted on immunization by an early upregulation of TGF-β on several hepatic structures (vascular endothelium, Kupffer cells, and hepatocytes), the data suggest that the specific hepatic microenvironment might contribute also to the faster recovery of these rats from EAE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Grubić-Kezele, Tanja& Blagojević Zagorac, Gordana& Jakovac, Hrvoje& Domitrović, Robert& Milin, Čedomila& Radošević-Stašić, Biserka. 2013. Hepatic Expression of Metallothionein III, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-495768
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Grubić-Kezele, Tanja…[et al.]. Hepatic Expression of Metallothionein III, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis. Clinical and Developmental Immunology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-495768
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Grubić-Kezele, Tanja& Blagojević Zagorac, Gordana& Jakovac, Hrvoje& Domitrović, Robert& Milin, Čedomila& Radošević-Stašić, Biserka. Hepatic Expression of Metallothionein III, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-495768
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495768
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر