The Interplay between Inflammation and Fibrosis in Kidney Transplantation

المؤلفون المشاركون

Torres, Irina B.
Meseguer, Anna
Serón, Daniel
Sarró, Eduard
Moreso, Francesc

المصدر

BioMed Research International

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-06-04

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Serial surveillance renal allograft biopsies have shown that early subclinical inflammation constitutes a risk factor for the development of interstitial fibrosis.

More recently, it has been observed that persistent inflammation is also associated with fibrosis progression and chronic humoral rejection, two histological conditions associated with poor allograft survival.

Treatment of subclinical inflammation with steroid boluses prevents progression of fibrosis and preserves renal function in patients treated with a cyclosporine-based regimen.

Subclinical inflammation has been reduced after the introduction of tacrolimus based regimens, and it has been shown that immunosuppressive schedules that are effective in preventing acute rejection and subclinical inflammation may prevent the progression of fibrosis and chronic humoral rejection.

On the other hand, minimization protocols are associated with progression of fibrosis, and noncompliance with the immunosuppressive regime constitutes a major risk factor for chronic humoral rejection.

Thus, adequate immunosuppressive treatment, avoiding minimization strategies and reinforcing educational actions to prevent noncompliance, is at present an effective approach to combat the progression of fibrosis.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Torres, Irina B.& Moreso, Francesc& Sarró, Eduard& Meseguer, Anna& Serón, Daniel. 2014. The Interplay between Inflammation and Fibrosis in Kidney Transplantation. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-495790

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Torres, Irina B.…[et al.]. The Interplay between Inflammation and Fibrosis in Kidney Transplantation. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-495790

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Torres, Irina B.& Moreso, Francesc& Sarró, Eduard& Meseguer, Anna& Serón, Daniel. The Interplay between Inflammation and Fibrosis in Kidney Transplantation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-495790

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-495790