The Interplay between Inflammation and Fibrosis in Kidney Transplantation
Joint Authors
Torres, Irina B.
Meseguer, Anna
Serón, Daniel
Sarró, Eduard
Moreso, Francesc
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Serial surveillance renal allograft biopsies have shown that early subclinical inflammation constitutes a risk factor for the development of interstitial fibrosis.
More recently, it has been observed that persistent inflammation is also associated with fibrosis progression and chronic humoral rejection, two histological conditions associated with poor allograft survival.
Treatment of subclinical inflammation with steroid boluses prevents progression of fibrosis and preserves renal function in patients treated with a cyclosporine-based regimen.
Subclinical inflammation has been reduced after the introduction of tacrolimus based regimens, and it has been shown that immunosuppressive schedules that are effective in preventing acute rejection and subclinical inflammation may prevent the progression of fibrosis and chronic humoral rejection.
On the other hand, minimization protocols are associated with progression of fibrosis, and noncompliance with the immunosuppressive regime constitutes a major risk factor for chronic humoral rejection.
Thus, adequate immunosuppressive treatment, avoiding minimization strategies and reinforcing educational actions to prevent noncompliance, is at present an effective approach to combat the progression of fibrosis.
American Psychological Association (APA)
Torres, Irina B.& Moreso, Francesc& Sarró, Eduard& Meseguer, Anna& Serón, Daniel. 2014. The Interplay between Inflammation and Fibrosis in Kidney Transplantation. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-495790
Modern Language Association (MLA)
Torres, Irina B.…[et al.]. The Interplay between Inflammation and Fibrosis in Kidney Transplantation. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-495790
American Medical Association (AMA)
Torres, Irina B.& Moreso, Francesc& Sarró, Eduard& Meseguer, Anna& Serón, Daniel. The Interplay between Inflammation and Fibrosis in Kidney Transplantation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-495790
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495790