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Inhalation of Ortho-Phthalaldehyde Vapor Causes Respiratory Sensitization in Mice
المؤلفون المشاركون
Yucesoy, Berran
Fluharty, Kara
Reynolds, Jeffrey S.
Wang, Wei
Johnson, Victor J.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-07-14
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Ortho-Phthalaldehyde (OPA) has been approved for high-level sterilization of heat-sensitive medical instruments and is increasingly being used as a replacement in the healthcare industry for glutaraldehyde, a known sensitizer.
Numerous case reports have been published indicating workers and patients experiencing respiratory problems, anaphylaxis, skin reactivity, and systemic antibody production.
Our laboratory previously demonstrated that OPA is a dermal sensitizer in mice.
The goal of the present study was to determine if OPA is a respiratory sensitizer following inhalation exposure.
Mice were exposed to OPA vapor and airway and lymph nodes were examined for cytokine gene expression and alterations in lymphocyte populations.
Inhalation of OPA for 3 days resulted in a concentration-dependent increase in lymphocyte proliferation, mainly B lymphocytes, in the draining lymph nodes.
A secondary challenge of mice with OPA resulted in a dramatic increase in the population of B lymphocytes expressing IgE.
Expression of Th2 (IL-4, IL-5, and IL-13) and anti/proinflammatory (IL-10, TNFα, and IL-1β) cytokine genes was upregulated in the lymph nodes and the nasal mucosa.
Mice exposed to the higher concentrations of OPA-produced OPA-specific IgG1 antibodies indicating systemic sensitization.
These findings provide evidence that OPA has the potential to cause respiratory sensitization in mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Johnson, Victor J.& Reynolds, Jeffrey S.& Wang, Wei& Fluharty, Kara& Yucesoy, Berran. 2011. Inhalation of Ortho-Phthalaldehyde Vapor Causes Respiratory Sensitization in Mice. Journal of Allergy،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-495835
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Johnson, Victor J.…[et al.]. Inhalation of Ortho-Phthalaldehyde Vapor Causes Respiratory Sensitization in Mice. Journal of Allergy No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-495835
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Johnson, Victor J.& Reynolds, Jeffrey S.& Wang, Wei& Fluharty, Kara& Yucesoy, Berran. Inhalation of Ortho-Phthalaldehyde Vapor Causes Respiratory Sensitization in Mice. Journal of Allergy. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-495835
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495835
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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