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Inhalation of Ortho-Phthalaldehyde Vapor Causes Respiratory Sensitization in Mice
Joint Authors
Yucesoy, Berran
Fluharty, Kara
Reynolds, Jeffrey S.
Wang, Wei
Johnson, Victor J.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Ortho-Phthalaldehyde (OPA) has been approved for high-level sterilization of heat-sensitive medical instruments and is increasingly being used as a replacement in the healthcare industry for glutaraldehyde, a known sensitizer.
Numerous case reports have been published indicating workers and patients experiencing respiratory problems, anaphylaxis, skin reactivity, and systemic antibody production.
Our laboratory previously demonstrated that OPA is a dermal sensitizer in mice.
The goal of the present study was to determine if OPA is a respiratory sensitizer following inhalation exposure.
Mice were exposed to OPA vapor and airway and lymph nodes were examined for cytokine gene expression and alterations in lymphocyte populations.
Inhalation of OPA for 3 days resulted in a concentration-dependent increase in lymphocyte proliferation, mainly B lymphocytes, in the draining lymph nodes.
A secondary challenge of mice with OPA resulted in a dramatic increase in the population of B lymphocytes expressing IgE.
Expression of Th2 (IL-4, IL-5, and IL-13) and anti/proinflammatory (IL-10, TNFα, and IL-1β) cytokine genes was upregulated in the lymph nodes and the nasal mucosa.
Mice exposed to the higher concentrations of OPA-produced OPA-specific IgG1 antibodies indicating systemic sensitization.
These findings provide evidence that OPA has the potential to cause respiratory sensitization in mice.
American Psychological Association (APA)
Johnson, Victor J.& Reynolds, Jeffrey S.& Wang, Wei& Fluharty, Kara& Yucesoy, Berran. 2011. Inhalation of Ortho-Phthalaldehyde Vapor Causes Respiratory Sensitization in Mice. Journal of Allergy،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-495835
Modern Language Association (MLA)
Johnson, Victor J.…[et al.]. Inhalation of Ortho-Phthalaldehyde Vapor Causes Respiratory Sensitization in Mice. Journal of Allergy No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-495835
American Medical Association (AMA)
Johnson, Victor J.& Reynolds, Jeffrey S.& Wang, Wei& Fluharty, Kara& Yucesoy, Berran. Inhalation of Ortho-Phthalaldehyde Vapor Causes Respiratory Sensitization in Mice. Journal of Allergy. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-495835
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495835