Circulating miR-583 and miR-663 Refer to ZHENG Differentiation in Chronic Hepatitis B
المؤلفون المشاركون
Lu, Yi-yu
Hu, Yi-Yang
Zhang, Hui
Huang, Shuang
Guan, Yan
Su, Shi-Bing
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-10
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Traditional Chinese medicine (TCM) ZHENG as the key pathological principle is to understand the human homeostasis and guide TCM treatment.
Here, circulating microRNAs (miRNAs) were utilized to differentiate between ZHENGs including liver-gallbladder dampness-heat syndrome (LGDHS) and liver-kidney yin deficiency syndrome (LKYDS) in chronic hepatitis B (CHB).
Sera samples of CHB patients with LGDHS (n=35), LKYDS (n=24), and healthy controls (Ctrls, n=21) were analyzed by microarray and real-time RT-PCR.
Receiver-operator characteristic (ROC) curves were established to evaluate the levels of serum miRNA for discriminating LGDHS and LKYDS.
The target genes of miRNAs were predicted by TargetScan.
Gene Ontology (GO) and pathways were analyzed using DAVID tool.
The results showed that 22 miRNAs were differentially expressed between LGDHS and LKYDS (fold change >2.0 and P<0.01).
Circulating miR-583 and miR-663 were significantly higher (P<0.001) in CHB patients with LGDHS than those with LKYDS and Ctrls.
ROC curve analysis revealed that miR-583 and miR-663 were sensitive and specific enough to distinguish LGDHS from LKYDS.
Pathway enrichment analysis indicated that 354 putative targets for miR-583 and 68 putative targets for miR-663 were mainly involved in Axon guidance, Neurotrophin, and MAPK signaling pathway.
miR-583 and miR-663 may be potential markers for ZHENG differentiation in CHB.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Hui& Guan, Yan& Lu, Yi-yu& Hu, Yi-Yang& Huang, Shuang& Su, Shi-Bing. 2013. Circulating miR-583 and miR-663 Refer to ZHENG Differentiation in Chronic Hepatitis B. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-495850
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Hui…[et al.]. Circulating miR-583 and miR-663 Refer to ZHENG Differentiation in Chronic Hepatitis B. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-495850
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Hui& Guan, Yan& Lu, Yi-yu& Hu, Yi-Yang& Huang, Shuang& Su, Shi-Bing. Circulating miR-583 and miR-663 Refer to ZHENG Differentiation in Chronic Hepatitis B. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-495850
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495850
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر