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Circulating miR-583 and miR-663 Refer to ZHENG Differentiation in Chronic Hepatitis B
Joint Authors
Lu, Yi-yu
Hu, Yi-Yang
Zhang, Hui
Huang, Shuang
Guan, Yan
Su, Shi-Bing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Traditional Chinese medicine (TCM) ZHENG as the key pathological principle is to understand the human homeostasis and guide TCM treatment.
Here, circulating microRNAs (miRNAs) were utilized to differentiate between ZHENGs including liver-gallbladder dampness-heat syndrome (LGDHS) and liver-kidney yin deficiency syndrome (LKYDS) in chronic hepatitis B (CHB).
Sera samples of CHB patients with LGDHS (n=35), LKYDS (n=24), and healthy controls (Ctrls, n=21) were analyzed by microarray and real-time RT-PCR.
Receiver-operator characteristic (ROC) curves were established to evaluate the levels of serum miRNA for discriminating LGDHS and LKYDS.
The target genes of miRNAs were predicted by TargetScan.
Gene Ontology (GO) and pathways were analyzed using DAVID tool.
The results showed that 22 miRNAs were differentially expressed between LGDHS and LKYDS (fold change >2.0 and P<0.01).
Circulating miR-583 and miR-663 were significantly higher (P<0.001) in CHB patients with LGDHS than those with LKYDS and Ctrls.
ROC curve analysis revealed that miR-583 and miR-663 were sensitive and specific enough to distinguish LGDHS from LKYDS.
Pathway enrichment analysis indicated that 354 putative targets for miR-583 and 68 putative targets for miR-663 were mainly involved in Axon guidance, Neurotrophin, and MAPK signaling pathway.
miR-583 and miR-663 may be potential markers for ZHENG differentiation in CHB.
American Psychological Association (APA)
Zhang, Hui& Guan, Yan& Lu, Yi-yu& Hu, Yi-Yang& Huang, Shuang& Su, Shi-Bing. 2013. Circulating miR-583 and miR-663 Refer to ZHENG Differentiation in Chronic Hepatitis B. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-495850
Modern Language Association (MLA)
Zhang, Hui…[et al.]. Circulating miR-583 and miR-663 Refer to ZHENG Differentiation in Chronic Hepatitis B. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-495850
American Medical Association (AMA)
Zhang, Hui& Guan, Yan& Lu, Yi-yu& Hu, Yi-Yang& Huang, Shuang& Su, Shi-Bing. Circulating miR-583 and miR-663 Refer to ZHENG Differentiation in Chronic Hepatitis B. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-495850
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495850