The Renin-Angiotensin System Modulates Inflammatory Processes in Atherosclerosis : Evidence from Basic Research and Clinical Studies

المؤلفون المشاركون

Montecucco, Fabrizio
Pende, Aldo
Mach, François

المصدر

Mediators of Inflammation

العدد

المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-13، 13ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2009-04-14

دولة النشر

مصر

عدد الصفحات

13

التخصصات الرئيسية

الأمراض

الملخص EN

Recent evidence shows that the renin-angiotensin system is a crucial player in atherosclerotic processes.

The regulation of arterial blood pressure was considered from its first description of the main mechanism involved.

Vasoconstriction (mediated by angiotensin II) and salt and water retention (mainly due to aldosterone) were classically considered as pivotal proatherosclerotic activities.

However, basic research and animal studies strongly support angiotensin II as a proinflammatory mediator, which directly induces atherosclerotic plaque development and heart remodeling.

Furthermore, angiotensin II induces proatherosclerotic cytokine and chemokine secretion and increases endothelial dysfunction.

Accordingly, the pharmacological inhibition of the renin-angiotensin system improves prognosis of patients with cardiovascular disease even in settings of normal baseline blood pressure.

In the present review, we focused on angiotensin-convertingenzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), and renin inhibitors to update the direct activities of the renin-angiotensin system in inflammatory processes governing atherosclerosis.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Montecucco, Fabrizio& Pende, Aldo& Mach, François. 2009. The Renin-Angiotensin System Modulates Inflammatory Processes in Atherosclerosis : Evidence from Basic Research and Clinical Studies. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-495942

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Montecucco, Fabrizio…[et al.]. The Renin-Angiotensin System Modulates Inflammatory Processes in Atherosclerosis : Evidence from Basic Research and Clinical Studies. Mediators of Inflammation No. 2009 (2009), pp.1-13.
https://search.emarefa.net/detail/BIM-495942

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Montecucco, Fabrizio& Pende, Aldo& Mach, François. The Renin-Angiotensin System Modulates Inflammatory Processes in Atherosclerosis : Evidence from Basic Research and Clinical Studies. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-495942

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-495942