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The Renin-Angiotensin System Modulates Inflammatory Processes in Atherosclerosis : Evidence from Basic Research and Clinical Studies
Joint Authors
Montecucco, Fabrizio
Pende, Aldo
Mach, François
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Recent evidence shows that the renin-angiotensin system is a crucial player in atherosclerotic processes.
The regulation of arterial blood pressure was considered from its first description of the main mechanism involved.
Vasoconstriction (mediated by angiotensin II) and salt and water retention (mainly due to aldosterone) were classically considered as pivotal proatherosclerotic activities.
However, basic research and animal studies strongly support angiotensin II as a proinflammatory mediator, which directly induces atherosclerotic plaque development and heart remodeling.
Furthermore, angiotensin II induces proatherosclerotic cytokine and chemokine secretion and increases endothelial dysfunction.
Accordingly, the pharmacological inhibition of the renin-angiotensin system improves prognosis of patients with cardiovascular disease even in settings of normal baseline blood pressure.
In the present review, we focused on angiotensin-convertingenzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), and renin inhibitors to update the direct activities of the renin-angiotensin system in inflammatory processes governing atherosclerosis.
American Psychological Association (APA)
Montecucco, Fabrizio& Pende, Aldo& Mach, François. 2009. The Renin-Angiotensin System Modulates Inflammatory Processes in Atherosclerosis : Evidence from Basic Research and Clinical Studies. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-495942
Modern Language Association (MLA)
Montecucco, Fabrizio…[et al.]. The Renin-Angiotensin System Modulates Inflammatory Processes in Atherosclerosis : Evidence from Basic Research and Clinical Studies. Mediators of Inflammation No. 2009 (2009), pp.1-13.
https://search.emarefa.net/detail/BIM-495942
American Medical Association (AMA)
Montecucco, Fabrizio& Pende, Aldo& Mach, François. The Renin-Angiotensin System Modulates Inflammatory Processes in Atherosclerosis : Evidence from Basic Research and Clinical Studies. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-495942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495942