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Antiproliferative Activity of the Isofuranonaphthoquinone Isolated from Bulbine frutescens against Jurkat T Cells
المؤلفون المشاركون
Mukanganyama, Stanley
Abegaz, Berhanu
Tambama, Penelope
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-16
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Cancer is a major public health burden in both developed and developing countries.
The quinone moiety has been shown to possess antitumor activity and several cancer drugs in clinical use contain this entity.
The effect of isofuranonaphthoquinone isolated from Bulbine frutescens on Jurkat T cells was determined.
Cells were exposed to the isofuranonaphthoquinone (IFNQ) at different concentrations.
Significant antiproliferative effects were observed which were comparable to that of the anticancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
A combination of IFNQ with BCNU produced synergistic effects which were observed after 72 hrs.
It was also observed that combining IFNQ with reduced glutathione abolished the anticancer activity of the compound.
It is, therefore, proposed that the isofuranonaphthoquinone may exert part of its effect by producing reactive oxygen species resulting in death of the cells as the effects of this compound were antagonized by reduced glutathione.
An investigation on the effects of isofuranonaphthoquinone on glutathione transferase (GST) activity and drug efflux pumps showed that this compound exhibited inhibitory effects on both the GST and the drug efflux pumping activities.
Thus, the isofuranonaphthoquinone showed cytotoxicity, works through inhibition of some cellular mechanisms, and could present a potential source of lead compounds for anticancer drug development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tambama, Penelope& Abegaz, Berhanu& Mukanganyama, Stanley. 2014. Antiproliferative Activity of the Isofuranonaphthoquinone Isolated from Bulbine frutescens against Jurkat T Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-496002
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tambama, Penelope…[et al.]. Antiproliferative Activity of the Isofuranonaphthoquinone Isolated from Bulbine frutescens against Jurkat T Cells. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-496002
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tambama, Penelope& Abegaz, Berhanu& Mukanganyama, Stanley. Antiproliferative Activity of the Isofuranonaphthoquinone Isolated from Bulbine frutescens against Jurkat T Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-496002
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496002
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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