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Antiproliferative Activity of the Isofuranonaphthoquinone Isolated from Bulbine frutescens against Jurkat T Cells
Joint Authors
Mukanganyama, Stanley
Abegaz, Berhanu
Tambama, Penelope
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Cancer is a major public health burden in both developed and developing countries.
The quinone moiety has been shown to possess antitumor activity and several cancer drugs in clinical use contain this entity.
The effect of isofuranonaphthoquinone isolated from Bulbine frutescens on Jurkat T cells was determined.
Cells were exposed to the isofuranonaphthoquinone (IFNQ) at different concentrations.
Significant antiproliferative effects were observed which were comparable to that of the anticancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
A combination of IFNQ with BCNU produced synergistic effects which were observed after 72 hrs.
It was also observed that combining IFNQ with reduced glutathione abolished the anticancer activity of the compound.
It is, therefore, proposed that the isofuranonaphthoquinone may exert part of its effect by producing reactive oxygen species resulting in death of the cells as the effects of this compound were antagonized by reduced glutathione.
An investigation on the effects of isofuranonaphthoquinone on glutathione transferase (GST) activity and drug efflux pumps showed that this compound exhibited inhibitory effects on both the GST and the drug efflux pumping activities.
Thus, the isofuranonaphthoquinone showed cytotoxicity, works through inhibition of some cellular mechanisms, and could present a potential source of lead compounds for anticancer drug development.
American Psychological Association (APA)
Tambama, Penelope& Abegaz, Berhanu& Mukanganyama, Stanley. 2014. Antiproliferative Activity of the Isofuranonaphthoquinone Isolated from Bulbine frutescens against Jurkat T Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-496002
Modern Language Association (MLA)
Tambama, Penelope…[et al.]. Antiproliferative Activity of the Isofuranonaphthoquinone Isolated from Bulbine frutescens against Jurkat T Cells. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-496002
American Medical Association (AMA)
Tambama, Penelope& Abegaz, Berhanu& Mukanganyama, Stanley. Antiproliferative Activity of the Isofuranonaphthoquinone Isolated from Bulbine frutescens against Jurkat T Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-496002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496002