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Antiosteoporosis Effect of Radix Scutellariae Extract on Density and Microstructure of Long Bones in Tail-Suspended Sprague-Dawley Rats
المؤلفون المشاركون
Li, Chen-Rui
Niu, Yin-Bo
Zhai, Yuan-Kun
Mei, Qi-Bing
Zhang, Guang-Wei
Pan, Ya-Lei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Radix Scutellariae (RS), a medicinal herb, is extensively employed in traditional Chinese medicines and modern herbal prescriptions.
Two major flavonoids in RS were known to induce osteoblastic differentiation and inhibit osteoclast differentiation, respectively.
This study aimed to investigate the effect of Radix Scutellariae extract (RSE) against bone loss induced by mechanical inactivity or weightlessness.
A hindlimb unloading tail-suspended rat model (TS) was established to determine the effect of RSE on bone mineral density and bone microarchitecture.
Treatment of RSE at 50 mg/kg/day and alendronate (ALE) at 2 mg/kg/day as positive control for 42 days significantly increased the bone mineral density and mechanical strength compared with TS group.
Enhanced bone turnover markers by TS treatment were attenuated by RSE and ALE administration.
Deterioration of bone trabecula induced by TS was prevented.
Moreover, both treatments counteracted the reduction of bone volume fraction, trabecular thickness and number, and connectivity density.
In conclusion, RSE was demonstrated for the first time to prevent osteoporosis induced by TS treatment, which suggests the potential application of RSE in the treatment of disuse-induced osteoporosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Chen-Rui& Zhang, Guang-Wei& Niu, Yin-Bo& Pan, Ya-Lei& Zhai, Yuan-Kun& Mei, Qi-Bing. 2013. Antiosteoporosis Effect of Radix Scutellariae Extract on Density and Microstructure of Long Bones in Tail-Suspended Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-496075
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Chen-Rui…[et al.]. Antiosteoporosis Effect of Radix Scutellariae Extract on Density and Microstructure of Long Bones in Tail-Suspended Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-496075
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Chen-Rui& Zhang, Guang-Wei& Niu, Yin-Bo& Pan, Ya-Lei& Zhai, Yuan-Kun& Mei, Qi-Bing. Antiosteoporosis Effect of Radix Scutellariae Extract on Density and Microstructure of Long Bones in Tail-Suspended Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-496075
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496075
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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