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Antiosteoporosis Effect of Radix Scutellariae Extract on Density and Microstructure of Long Bones in Tail-Suspended Sprague-Dawley Rats
Joint Authors
Li, Chen-Rui
Niu, Yin-Bo
Zhai, Yuan-Kun
Mei, Qi-Bing
Zhang, Guang-Wei
Pan, Ya-Lei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Radix Scutellariae (RS), a medicinal herb, is extensively employed in traditional Chinese medicines and modern herbal prescriptions.
Two major flavonoids in RS were known to induce osteoblastic differentiation and inhibit osteoclast differentiation, respectively.
This study aimed to investigate the effect of Radix Scutellariae extract (RSE) against bone loss induced by mechanical inactivity or weightlessness.
A hindlimb unloading tail-suspended rat model (TS) was established to determine the effect of RSE on bone mineral density and bone microarchitecture.
Treatment of RSE at 50 mg/kg/day and alendronate (ALE) at 2 mg/kg/day as positive control for 42 days significantly increased the bone mineral density and mechanical strength compared with TS group.
Enhanced bone turnover markers by TS treatment were attenuated by RSE and ALE administration.
Deterioration of bone trabecula induced by TS was prevented.
Moreover, both treatments counteracted the reduction of bone volume fraction, trabecular thickness and number, and connectivity density.
In conclusion, RSE was demonstrated for the first time to prevent osteoporosis induced by TS treatment, which suggests the potential application of RSE in the treatment of disuse-induced osteoporosis.
American Psychological Association (APA)
Li, Chen-Rui& Zhang, Guang-Wei& Niu, Yin-Bo& Pan, Ya-Lei& Zhai, Yuan-Kun& Mei, Qi-Bing. 2013. Antiosteoporosis Effect of Radix Scutellariae Extract on Density and Microstructure of Long Bones in Tail-Suspended Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-496075
Modern Language Association (MLA)
Li, Chen-Rui…[et al.]. Antiosteoporosis Effect of Radix Scutellariae Extract on Density and Microstructure of Long Bones in Tail-Suspended Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-496075
American Medical Association (AMA)
Li, Chen-Rui& Zhang, Guang-Wei& Niu, Yin-Bo& Pan, Ya-Lei& Zhai, Yuan-Kun& Mei, Qi-Bing. Antiosteoporosis Effect of Radix Scutellariae Extract on Density and Microstructure of Long Bones in Tail-Suspended Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-496075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496075