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The Putative Role of the Antiageing Protein Klotho in Cardiovascular and Renal Disease
المؤلفون المشاركون
Karalliedde, Janaka
Maltese, Giuseppe
المصدر
International Journal of Hypertension
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-10-29
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Ageing is a multifactorial process often characterized by a progressive decline in physiological function(s).
Ageing can and is often associated with an increased incidence of cardiovascular and renal disease.
Klotho is a novel antiageing gene that encodes a protein with multiple pleiotropic functions including an emerging role in cardiorenal disease.
Mice deficient for this gene display a phenotype of premature human ageing characterized by diffuse vascular calcification, altered calcium/phosphate metabolism, and shortened lifespan.
Klotho is mainly expressed in the renal tubules but it also exists as circulating soluble form detectable in the blood, with systemic effects.
Reduction in soluble Klotho has been associated with renal disease, hyperphosphataemia, increased oxidative stress, endothelial dysfunction, and diffuse vascular calcification.
Conversely, overexpression of Klotho promotes cardiovascular-renal protection.
The majority of the research on Klotho has been conducted in vitro and in animal studies but there is emerging data from human studies which suggest that Klotho may be a modifiable factor involved in the pathogenesis of cardiovascular and renal disease in at-risk populations.
Further data is required to confirm if this novel protein can emerge as therapeutic tool that may be used to prevent or slow progression of cardiorenal disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maltese, Giuseppe& Karalliedde, Janaka. 2011. The Putative Role of the Antiageing Protein Klotho in Cardiovascular and Renal Disease. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-496349
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maltese, Giuseppe& Karalliedde, Janaka. The Putative Role of the Antiageing Protein Klotho in Cardiovascular and Renal Disease. International Journal of Hypertension No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-496349
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maltese, Giuseppe& Karalliedde, Janaka. The Putative Role of the Antiageing Protein Klotho in Cardiovascular and Renal Disease. International Journal of Hypertension. 2011. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-496349
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496349
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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