![](/images/graphics-bg.png)
Ethanolic Extract of Polish Propolis : Chemical Composition and TRAIL-R2 Death Receptor Targeting Apoptotic Activity against Prostate Cancer Cells
المؤلفون المشاركون
Jaworska, Dagmara
Kucharska, Alicja Z.
Sokół-Łętowska, Anna
Szliszka, Ewelina
Czuba, Zenon P.
Krol, Wojciech
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-12
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Propolis possesses chemopreventive properties through direct anticancer and indirect immunomodulatory activities.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plays a significant role in immunosurveillance and defense against cancer cells.
TRAIL triggers apoptosis upon binding to TRAIL-R1 (DR4) and TRAIL-R2 (DR5) death receptors expressed on cancer cell surface.
The activation of TRAIL apoptotic signaling is considered an attractive option for cancer prevention.
However, as more tumor cells are reported to be resistant to TRAIL-mediated death, it is important to develop new strategies to overcome this resistance.
The aim of this study was to investigate the chemical composition and proapoptotic mechanism of ethanolic extract of Polish propolis (EEP-P) against cancer cells.
The identification and quantification of phenolic compounds in propolis extract were performed using HPLC-DAD and UPLC-Q-TOF-MS methods.
TRAIL-resistant LNCaP prostate cancer cells were treated with EEP-P and TRAIL.
Cytotoxicity was measured by MTT and LDH assays.
Apoptosis was detected using annexin V-FITC staining by flow cytometry and fluorescence microscopy.
Death receptors expression was analyzed using flow cytometry.
Pinobanksin, chrysin, methoxyflavanone, p-coumaric acid, ferulic acid and caffeic acid were the main phenolics found in EEP-P.
Propolis sensitized LNCaP cells through upregulation of TRAIL-R2.
These results suggest that EEP-P supports TRAIL-mediated immunochemoprevention in prostate cancer cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Szliszka, Ewelina& Sokół-Łętowska, Anna& Kucharska, Alicja Z.& Jaworska, Dagmara& Czuba, Zenon P.& Krol, Wojciech. 2013. Ethanolic Extract of Polish Propolis : Chemical Composition and TRAIL-R2 Death Receptor Targeting Apoptotic Activity against Prostate Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-496364
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Szliszka, Ewelina…[et al.]. Ethanolic Extract of Polish Propolis : Chemical Composition and TRAIL-R2 Death Receptor Targeting Apoptotic Activity against Prostate Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-496364
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Szliszka, Ewelina& Sokół-Łętowska, Anna& Kucharska, Alicja Z.& Jaworska, Dagmara& Czuba, Zenon P.& Krol, Wojciech. Ethanolic Extract of Polish Propolis : Chemical Composition and TRAIL-R2 Death Receptor Targeting Apoptotic Activity against Prostate Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-496364
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496364
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)