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Development of New Method for Simultaneous Analysis of Piracetam and Levetiracetam in Pharmaceuticals and Biological Fluids : Application in Stability Studies
المؤلفون المشاركون
Mehjebeen,
Shafi, Nighat
Ahmad, Mansur
Naseem, Huma
Wafa Sial, Alisha
Siddiqui, Farhan Ahmed
Sher, Nawab
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
RP-HPLC ultraviolet detection simultaneous quantification of piracetam and levetiracetam has been developed and validated.
The chromatography was obtained on a Nucleosil C18 column of 25 cm×0.46 cm, 10 μm, dimension.
The mobile phase was a (70 : 30 v/v) mixture of 0.1 g/L of triethylamine and acetonitrile.
Smooth flow of mobile phase at 1 mL/min was set and 205 nm wavelength was selected.
Results were evaluated through statistical parameters which qualify the method reproducibility and selectivity for the quantification of piracetam, levetiracetam, and their impurities hence proving stability-indicating properties.
The proposed method is significantly important, permitting the separation of the main constituent piracetam from levetiracetam.
Linear behavior was observed between 20 ng/mL and 10000 ng/mL for both drugs.
The proposed method was checked in bulk drugs, dosage formulations, physiological condition, and clinical investigations and excellent outcome was witnessed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Siddiqui, Farhan Ahmed& Sher, Nawab& Shafi, Nighat& Wafa Sial, Alisha& Ahmad, Mansur& Mehjebeen,…[et al.]. 2014. Development of New Method for Simultaneous Analysis of Piracetam and Levetiracetam in Pharmaceuticals and Biological Fluids : Application in Stability Studies. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-496415
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Siddiqui, Farhan Ahmed…[et al.]. Development of New Method for Simultaneous Analysis of Piracetam and Levetiracetam in Pharmaceuticals and Biological Fluids : Application in Stability Studies. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-496415
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Siddiqui, Farhan Ahmed& Sher, Nawab& Shafi, Nighat& Wafa Sial, Alisha& Ahmad, Mansur& Mehjebeen,…[et al.]. Development of New Method for Simultaneous Analysis of Piracetam and Levetiracetam in Pharmaceuticals and Biological Fluids : Application in Stability Studies. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-496415
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496415
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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