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Development of New Method for Simultaneous Analysis of Piracetam and Levetiracetam in Pharmaceuticals and Biological Fluids : Application in Stability Studies
Joint Authors
Mehjebeen,
Shafi, Nighat
Ahmad, Mansur
Naseem, Huma
Wafa Sial, Alisha
Siddiqui, Farhan Ahmed
Sher, Nawab
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
RP-HPLC ultraviolet detection simultaneous quantification of piracetam and levetiracetam has been developed and validated.
The chromatography was obtained on a Nucleosil C18 column of 25 cm×0.46 cm, 10 μm, dimension.
The mobile phase was a (70 : 30 v/v) mixture of 0.1 g/L of triethylamine and acetonitrile.
Smooth flow of mobile phase at 1 mL/min was set and 205 nm wavelength was selected.
Results were evaluated through statistical parameters which qualify the method reproducibility and selectivity for the quantification of piracetam, levetiracetam, and their impurities hence proving stability-indicating properties.
The proposed method is significantly important, permitting the separation of the main constituent piracetam from levetiracetam.
Linear behavior was observed between 20 ng/mL and 10000 ng/mL for both drugs.
The proposed method was checked in bulk drugs, dosage formulations, physiological condition, and clinical investigations and excellent outcome was witnessed.
American Psychological Association (APA)
Siddiqui, Farhan Ahmed& Sher, Nawab& Shafi, Nighat& Wafa Sial, Alisha& Ahmad, Mansur& Mehjebeen,…[et al.]. 2014. Development of New Method for Simultaneous Analysis of Piracetam and Levetiracetam in Pharmaceuticals and Biological Fluids : Application in Stability Studies. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-496415
Modern Language Association (MLA)
Siddiqui, Farhan Ahmed…[et al.]. Development of New Method for Simultaneous Analysis of Piracetam and Levetiracetam in Pharmaceuticals and Biological Fluids : Application in Stability Studies. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-496415
American Medical Association (AMA)
Siddiqui, Farhan Ahmed& Sher, Nawab& Shafi, Nighat& Wafa Sial, Alisha& Ahmad, Mansur& Mehjebeen,…[et al.]. Development of New Method for Simultaneous Analysis of Piracetam and Levetiracetam in Pharmaceuticals and Biological Fluids : Application in Stability Studies. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-496415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496415