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Plasminogen Binding Proteins and Plasmin Generation on the Surface of Leptospira spp. : The Contribution to the Bacteria-Host Interactions
المؤلفون المشاركون
Mendes, Renata S.
Vasconcellos, Silvio A.
Oliveira, Rosane
Domingos, Renan F.
Nascimento, Ana L. T. O.
Atzingen, Marina V.
Vieira, Monica L.
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-15
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Leptospirosis is considered a neglected infectious disease of human and veterinary concern.
Although extensive investigations on host-pathogen interactions have been pursued by several research groups, mechanisms of infection, invasion and persistence of pathogenic Leptospira spp.
remain to be elucidated.
We have reported the ability of leptospires to bind human plasminogen (PLG) and to generate enzimatically active plasmin (PLA) on the bacteria surface.
PLA-coated Leptospira can degrade immobilized ECM molecules, an activity with implications in host tissue penetration.
Moreover, we have identified and characterized several proteins that may act as PLG-binding receptors, each of them competent to generate active plasmin.
The PLA activity associated to the outer surface of Leptospira could hamper the host immune attack by conferring the bacteria some benefit during infection.
The PLA-coated leptospires obstruct complement C3b and IgG depositions on the bacterial surface, most probably through degradation.
The decrease of leptospiral opsonization might be an important aspect of the immune evasion strategy.
We believe that the presence of PLA on the leptospiral surface may (i) facilitate host tissue penetration, (ii) help the bacteria to evade the immune system and, as a consequence, (iii) permit Leptospira to reach secondary sites of infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vieira, Monica L.& Atzingen, Marina V.& Oliveira, Rosane& Mendes, Renata S.& Domingos, Renan F.& Vasconcellos, Silvio A.…[et al.]. 2012. Plasminogen Binding Proteins and Plasmin Generation on the Surface of Leptospira spp. : The Contribution to the Bacteria-Host Interactions. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-496435
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vieira, Monica L.…[et al.]. Plasminogen Binding Proteins and Plasmin Generation on the Surface of Leptospira spp. : The Contribution to the Bacteria-Host Interactions. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-496435
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vieira, Monica L.& Atzingen, Marina V.& Oliveira, Rosane& Mendes, Renata S.& Domingos, Renan F.& Vasconcellos, Silvio A.…[et al.]. Plasminogen Binding Proteins and Plasmin Generation on the Surface of Leptospira spp. : The Contribution to the Bacteria-Host Interactions. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-496435
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496435
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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