Plasminogen Binding Proteins and Plasmin Generation on the Surface of Leptospira spp. : The Contribution to the Bacteria-Host Interactions
Joint Authors
Mendes, Renata S.
Vasconcellos, Silvio A.
Oliveira, Rosane
Domingos, Renan F.
Nascimento, Ana L. T. O.
Atzingen, Marina V.
Vieira, Monica L.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-15
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Leptospirosis is considered a neglected infectious disease of human and veterinary concern.
Although extensive investigations on host-pathogen interactions have been pursued by several research groups, mechanisms of infection, invasion and persistence of pathogenic Leptospira spp.
remain to be elucidated.
We have reported the ability of leptospires to bind human plasminogen (PLG) and to generate enzimatically active plasmin (PLA) on the bacteria surface.
PLA-coated Leptospira can degrade immobilized ECM molecules, an activity with implications in host tissue penetration.
Moreover, we have identified and characterized several proteins that may act as PLG-binding receptors, each of them competent to generate active plasmin.
The PLA activity associated to the outer surface of Leptospira could hamper the host immune attack by conferring the bacteria some benefit during infection.
The PLA-coated leptospires obstruct complement C3b and IgG depositions on the bacterial surface, most probably through degradation.
The decrease of leptospiral opsonization might be an important aspect of the immune evasion strategy.
We believe that the presence of PLA on the leptospiral surface may (i) facilitate host tissue penetration, (ii) help the bacteria to evade the immune system and, as a consequence, (iii) permit Leptospira to reach secondary sites of infection.
American Psychological Association (APA)
Vieira, Monica L.& Atzingen, Marina V.& Oliveira, Rosane& Mendes, Renata S.& Domingos, Renan F.& Vasconcellos, Silvio A.…[et al.]. 2012. Plasminogen Binding Proteins and Plasmin Generation on the Surface of Leptospira spp. : The Contribution to the Bacteria-Host Interactions. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-496435
Modern Language Association (MLA)
Vieira, Monica L.…[et al.]. Plasminogen Binding Proteins and Plasmin Generation on the Surface of Leptospira spp. : The Contribution to the Bacteria-Host Interactions. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-496435
American Medical Association (AMA)
Vieira, Monica L.& Atzingen, Marina V.& Oliveira, Rosane& Mendes, Renata S.& Domingos, Renan F.& Vasconcellos, Silvio A.…[et al.]. Plasminogen Binding Proteins and Plasmin Generation on the Surface of Leptospira spp. : The Contribution to the Bacteria-Host Interactions. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-496435
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496435