![](/images/graphics-bg.png)
Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity
المؤلفون المشاركون
Van Cauter, Eve
Balbo, Marcella
Leproult, Rachel
المصدر
International Journal of Endocrinology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-06-09
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
The daily rhythm of cortisol secretion is relatively stable and primarily under the influence of the circadian clock.
Nevertheless, several other factors affect hypothalamo-pituitary-adrenal (HPA) axis activity.
Sleep has modest but clearly detectable modulatory effects on HPA axis activity.
Sleep onset exerts an inhibitory effect on cortisol secretion while awakenings and sleep offset are accompanied by cortisol stimulation.
During waking, an association between cortisol secretory bursts and indices of central arousal has also been detected.
Abrupt shifts of the sleep period induce a profound disruption in the daily cortisol rhythm, while sleep deprivation and/or reduced sleep quality seem to result in a modest but functionally important activation of the axis.
HPA hyperactivity is clearly associated with metabolic, cognitive and psychiatric disorders and could be involved in the well-documented associations between sleep disturbances and the risk of obesity, diabetes and cognitive dysfunction.
Several clinical syndromes, such as insomnia, depression, Cushing's syndrome, sleep disordered breathing (SDB) display HPA hyperactivity, disturbed sleep, psychiatric and metabolic impairments.
Further research to delineate the functional links between sleep and HPA axis activity is needed to fully understand the pathophysiology of these syndromes and to develop adequate strategies of prevention and treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Balbo, Marcella& Leproult, Rachel& Van Cauter, Eve. 2010. Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity. International Journal of Endocrinology،Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-496499
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Balbo, Marcella…[et al.]. Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity. International Journal of Endocrinology No. 2010 (2010), pp.1-16.
https://search.emarefa.net/detail/BIM-496499
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Balbo, Marcella& Leproult, Rachel& Van Cauter, Eve. Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity. International Journal of Endocrinology. 2010. Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-496499
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496499
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)