Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity
Joint Authors
Van Cauter, Eve
Balbo, Marcella
Leproult, Rachel
Source
International Journal of Endocrinology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-09
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The daily rhythm of cortisol secretion is relatively stable and primarily under the influence of the circadian clock.
Nevertheless, several other factors affect hypothalamo-pituitary-adrenal (HPA) axis activity.
Sleep has modest but clearly detectable modulatory effects on HPA axis activity.
Sleep onset exerts an inhibitory effect on cortisol secretion while awakenings and sleep offset are accompanied by cortisol stimulation.
During waking, an association between cortisol secretory bursts and indices of central arousal has also been detected.
Abrupt shifts of the sleep period induce a profound disruption in the daily cortisol rhythm, while sleep deprivation and/or reduced sleep quality seem to result in a modest but functionally important activation of the axis.
HPA hyperactivity is clearly associated with metabolic, cognitive and psychiatric disorders and could be involved in the well-documented associations between sleep disturbances and the risk of obesity, diabetes and cognitive dysfunction.
Several clinical syndromes, such as insomnia, depression, Cushing's syndrome, sleep disordered breathing (SDB) display HPA hyperactivity, disturbed sleep, psychiatric and metabolic impairments.
Further research to delineate the functional links between sleep and HPA axis activity is needed to fully understand the pathophysiology of these syndromes and to develop adequate strategies of prevention and treatment.
American Psychological Association (APA)
Balbo, Marcella& Leproult, Rachel& Van Cauter, Eve. 2010. Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity. International Journal of Endocrinology،Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-496499
Modern Language Association (MLA)
Balbo, Marcella…[et al.]. Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity. International Journal of Endocrinology No. 2010 (2010), pp.1-16.
https://search.emarefa.net/detail/BIM-496499
American Medical Association (AMA)
Balbo, Marcella& Leproult, Rachel& Van Cauter, Eve. Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity. International Journal of Endocrinology. 2010. Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-496499
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496499