![](/images/graphics-bg.png)
Aberrant Expression of N-Methylpurine-DNA Glycosylase Influences Patient Survival in Malignant Gliomas
المؤلفون المشاركون
Zong, Jianhai
Liu, Ce
Zhang, Yongsheng
He, Shiming
Wang, Liang
Yuan, Jun
Fu, Guoqiang
Mao, Xinggang
Tu, Yanyang
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
To examine the expression of N-methylpurine-DNA glycosylase (MPG) gene and protein in glioma samples with different WHO grades and its association with patients’ survival.
Methods.
Immunohistochemistry assay, quantitative real-time PCR and Western blot analysis were carried out to investigate the expression of MPG gene and protein in 128 glioma and 10 non-neoplastic brain tissues.
Results.
MPG gene expression level in glioma tissues was significantly higher than that in non-neoplastic brain tissues (P<0.001).
Immunohistochemistry also showed that MPG protein was over-expressed in glioma tissues, which was consistent with the resutls of Western blot analysis.
Additionally, the expression levels of MPG gene and protein both increase from grade I to grade IV glioma according to the results of real-time PCR, immunohistochemistry and western blot analysis.
Moreover, the survival rate of MPG-positive patients was significantly lower than that of MPG-negative patients (P<0.001).
We further confirmed that the over-expression of MPG was a significant and independent prognostic indicator in glioma by multivariate analysis (P<0.001).
Conclusions.
Our data showed the over-expression of MPG gene and protein in human gliomas, and also suggested for the first time that MPG be an unfavorable independent prognostic indicator for glioma patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Ce& Tu, Yanyang& Yuan, Jun& Mao, Xinggang& He, Shiming& Wang, Liang…[et al.]. 2012. Aberrant Expression of N-Methylpurine-DNA Glycosylase Influences Patient Survival in Malignant Gliomas. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-496623
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Ce…[et al.]. Aberrant Expression of N-Methylpurine-DNA Glycosylase Influences Patient Survival in Malignant Gliomas. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-496623
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Ce& Tu, Yanyang& Yuan, Jun& Mao, Xinggang& He, Shiming& Wang, Liang…[et al.]. Aberrant Expression of N-Methylpurine-DNA Glycosylase Influences Patient Survival in Malignant Gliomas. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-496623
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496623
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)