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Aberrant Expression of N-Methylpurine-DNA Glycosylase Influences Patient Survival in Malignant Gliomas
Joint Authors
Zong, Jianhai
Liu, Ce
Zhang, Yongsheng
He, Shiming
Wang, Liang
Yuan, Jun
Fu, Guoqiang
Mao, Xinggang
Tu, Yanyang
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
To examine the expression of N-methylpurine-DNA glycosylase (MPG) gene and protein in glioma samples with different WHO grades and its association with patients’ survival.
Methods.
Immunohistochemistry assay, quantitative real-time PCR and Western blot analysis were carried out to investigate the expression of MPG gene and protein in 128 glioma and 10 non-neoplastic brain tissues.
Results.
MPG gene expression level in glioma tissues was significantly higher than that in non-neoplastic brain tissues (P<0.001).
Immunohistochemistry also showed that MPG protein was over-expressed in glioma tissues, which was consistent with the resutls of Western blot analysis.
Additionally, the expression levels of MPG gene and protein both increase from grade I to grade IV glioma according to the results of real-time PCR, immunohistochemistry and western blot analysis.
Moreover, the survival rate of MPG-positive patients was significantly lower than that of MPG-negative patients (P<0.001).
We further confirmed that the over-expression of MPG was a significant and independent prognostic indicator in glioma by multivariate analysis (P<0.001).
Conclusions.
Our data showed the over-expression of MPG gene and protein in human gliomas, and also suggested for the first time that MPG be an unfavorable independent prognostic indicator for glioma patients.
American Psychological Association (APA)
Liu, Ce& Tu, Yanyang& Yuan, Jun& Mao, Xinggang& He, Shiming& Wang, Liang…[et al.]. 2012. Aberrant Expression of N-Methylpurine-DNA Glycosylase Influences Patient Survival in Malignant Gliomas. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-496623
Modern Language Association (MLA)
Liu, Ce…[et al.]. Aberrant Expression of N-Methylpurine-DNA Glycosylase Influences Patient Survival in Malignant Gliomas. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-496623
American Medical Association (AMA)
Liu, Ce& Tu, Yanyang& Yuan, Jun& Mao, Xinggang& He, Shiming& Wang, Liang…[et al.]. Aberrant Expression of N-Methylpurine-DNA Glycosylase Influences Patient Survival in Malignant Gliomas. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-496623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496623