Clitocybe nuda Activates Dendritic Cells and Acts as a DNA Vaccine Adjuvant
المؤلفون المشاركون
Chen, Der-Yuan
Ko, Ching-Huai
Lin, Sheng-Hao
Lin, Ching-Hsiung
Lue, Yun-Sheng
Chu, Ching-Liang
Lin, Chi-Chen
Chen, Mei-Hsing
Li, Wei-Sung
Chang, Chih-Peng
Pan, I-Horng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-22
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
This work represents the first evaluation of the effects of water extract of C.
nuda (WE-CN), an edible mushroom, on murine bone marrow-derived dendritic cells (BMDCs) and the potential pathway through which the effects are mediated.
Our experimental results show that WE-CN could induce phenotypic maturation of DCs, as shown by the increased expression of MHC and costimulatory molecules.
In addition, it also induced the proinflammatory cytokines expression on DCs and enhanced both the proliferation and IFN-γ secretion of allogenic T cells.
Therefore, since WE-CN did not induce maturation of DCs generated from mice with mutated TLR-4 or TLR-2, suggesting that TLR4 and TLR2 might function as membrane receptors for WE-CN.
Moreover, the mechanism of action of WE-CN may be mediated by increased phosphorylation of ERK, p38, and JNK mitogen-activated protein kinase (MAPK) and increased NF-κB p65 activity, which are important signaling molecules downstream of TLR-4 and TLR-2.
Finally, coimmunization of mice with WE-CN and a HER-2/neu DNA vaccine induced a HER-2/neu-specific Th1 response that resulted in significant inhibition of HER-2/neu overexpressing mouse bladder tumor (MBT-2) growth.
These data suggest that WE-CN induces DC maturation through TLR-4 and/or TLR-2 and that WE-CN can be used as an adjuvant in cancer vaccine immunotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Mei-Hsing& Li, Wei-Sung& Lue, Yun-Sheng& Chu, Ching-Liang& Pan, I-Horng& Ko, Ching-Huai…[et al.]. 2013. Clitocybe nuda Activates Dendritic Cells and Acts as a DNA Vaccine Adjuvant. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-496699
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Mei-Hsing…[et al.]. Clitocybe nuda Activates Dendritic Cells and Acts as a DNA Vaccine Adjuvant. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-496699
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Mei-Hsing& Li, Wei-Sung& Lue, Yun-Sheng& Chu, Ching-Liang& Pan, I-Horng& Ko, Ching-Huai…[et al.]. Clitocybe nuda Activates Dendritic Cells and Acts as a DNA Vaccine Adjuvant. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-496699
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496699
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر