Effect of Antioxidant Treatment on Fibrogenesis in Rats with Carbon Tetrachloride-Induced Cirrhosis
المؤلفون المشاركون
Filippin, Lidiane Isabel
Valiatti, Bruna
Bona, Sílvia
Di Naso, Fábio Cangeri
Isoppo Schaun, Maximiliano
de David, Cintia
Xavier, Ricardo Machado
Marroni, Norma Anair Possa
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-02
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aim.
This study aimed to assess the antioxidant activity of quercetin (Q) in an experimental model of cirrhosis induced by CCl4 inhalation.
Materials and Methods.
We used 25 male Wistar rats (250 g) that were divided into 3 groups: control (CO), CCl4, and CCl4+Q.
The rats were subjected to CCl4 inhalation (2x/week) for 16 weeks, and they received phenobarbital in their drinking water at a dose of 0.3 g/dL as a P450 enzyme inducer.
Q (50 mg/Kg) was initiated intraperitoneally at 10 weeks of inhalation and lasted until the end of the experiment.
Statistical analysis was by ANOVA Student Newman-Keuls (mean±SEM), and differences were considered statistically significant when P<0.05.
Results.
After treatment with quercetin, we observed an improvement in liver complications, decreased fibrosis, as analyzed by picrosirius for the quantification of collagen, and decreased levels of matrix metalloproteinase 2 (MMP-2) compared with the CCl4 group.
It also reduced oxidative stress, as confirmed by the decrease of substances reacting to thiobarbituric acid (TBARS), the increased activity of antioxidant enzymes, and the reduced glutathione ratio and glutathione disulfide (GSH/GSSG).
Conclusion.
We suggest that the use of quercetin might be promising as an antioxidant therapy in liver fibrosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bona, Sílvia& Filippin, Lidiane Isabel& Di Naso, Fábio Cangeri& de David, Cintia& Valiatti, Bruna& Isoppo Schaun, Maximiliano…[et al.]. 2012. Effect of Antioxidant Treatment on Fibrogenesis in Rats with Carbon Tetrachloride-Induced Cirrhosis. ISRN Gastroenterology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-496837
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bona, Sílvia…[et al.]. Effect of Antioxidant Treatment on Fibrogenesis in Rats with Carbon Tetrachloride-Induced Cirrhosis. ISRN Gastroenterology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-496837
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bona, Sílvia& Filippin, Lidiane Isabel& Di Naso, Fábio Cangeri& de David, Cintia& Valiatti, Bruna& Isoppo Schaun, Maximiliano…[et al.]. Effect of Antioxidant Treatment on Fibrogenesis in Rats with Carbon Tetrachloride-Induced Cirrhosis. ISRN Gastroenterology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-496837
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496837
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر