Effect of Antioxidant Treatment on Fibrogenesis in Rats with Carbon Tetrachloride-Induced Cirrhosis
Joint Authors
Filippin, Lidiane Isabel
Valiatti, Bruna
Bona, Sílvia
Di Naso, Fábio Cangeri
Isoppo Schaun, Maximiliano
de David, Cintia
Xavier, Ricardo Machado
Marroni, Norma Anair Possa
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
This study aimed to assess the antioxidant activity of quercetin (Q) in an experimental model of cirrhosis induced by CCl4 inhalation.
Materials and Methods.
We used 25 male Wistar rats (250 g) that were divided into 3 groups: control (CO), CCl4, and CCl4+Q.
The rats were subjected to CCl4 inhalation (2x/week) for 16 weeks, and they received phenobarbital in their drinking water at a dose of 0.3 g/dL as a P450 enzyme inducer.
Q (50 mg/Kg) was initiated intraperitoneally at 10 weeks of inhalation and lasted until the end of the experiment.
Statistical analysis was by ANOVA Student Newman-Keuls (mean±SEM), and differences were considered statistically significant when P<0.05.
Results.
After treatment with quercetin, we observed an improvement in liver complications, decreased fibrosis, as analyzed by picrosirius for the quantification of collagen, and decreased levels of matrix metalloproteinase 2 (MMP-2) compared with the CCl4 group.
It also reduced oxidative stress, as confirmed by the decrease of substances reacting to thiobarbituric acid (TBARS), the increased activity of antioxidant enzymes, and the reduced glutathione ratio and glutathione disulfide (GSH/GSSG).
Conclusion.
We suggest that the use of quercetin might be promising as an antioxidant therapy in liver fibrosis.
American Psychological Association (APA)
Bona, Sílvia& Filippin, Lidiane Isabel& Di Naso, Fábio Cangeri& de David, Cintia& Valiatti, Bruna& Isoppo Schaun, Maximiliano…[et al.]. 2012. Effect of Antioxidant Treatment on Fibrogenesis in Rats with Carbon Tetrachloride-Induced Cirrhosis. ISRN Gastroenterology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-496837
Modern Language Association (MLA)
Bona, Sílvia…[et al.]. Effect of Antioxidant Treatment on Fibrogenesis in Rats with Carbon Tetrachloride-Induced Cirrhosis. ISRN Gastroenterology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-496837
American Medical Association (AMA)
Bona, Sílvia& Filippin, Lidiane Isabel& Di Naso, Fábio Cangeri& de David, Cintia& Valiatti, Bruna& Isoppo Schaun, Maximiliano…[et al.]. Effect of Antioxidant Treatment on Fibrogenesis in Rats with Carbon Tetrachloride-Induced Cirrhosis. ISRN Gastroenterology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-496837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496837