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Anticancer Potential of Aqueous Ethanol Seed Extract of Ziziphus mauritiana against Cancer Cell Lines and Ehrlich Ascites Carcinoma
المؤلفون المشاركون
Mishra, Tulika
Bhatia, Aruna
Khullar, Madhu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-09-26
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Ziziphus mauritiana (Lamk.) is a fruit tree that has folkloric implications against many ailments and diseases.
In the present study, anticancer potential of seed extract of Ziziphus mauritiana in vitro against different cell lines (HL-60, Molt-4, HeLa, and normal cell line HGF) by MTT assay as well as in vivo against Ehrich ascites carcinoma bearing Swiss albino mice was investigated.
The extract was found to markedly inhibit the proliferation of HL-60 cells.
Annexin and PI binding of treated HL-60 cells indicated apoptosis induction by extract in a dose-dependent manner.
The cell cycle analysis revealed a prominent increase in sub Go population at concentration of 20 μg/ml and above.
Agarose gel electrophoresis confirmed DNA fragmentation in HL-60 cells after 3 h incubation with extract.
The extract also exhibited potent anticancer potential in vivo.
Treatment of Ehrlich ascites carcinoma bearing Swiss albino mice with varied doses (100–800 mg/kg b.wt.) of plant extract significantly reduced tumor volume and viable tumor cell count and improved haemoglobin content, RBC count, mean survival time, tumor inhibition, and percentage life span.
The enhanced antioxidant status in extract-treated animals was evident from decline in levels of lipid peroxidation and increased levels of glutathione, catalase, and superoxide dismutase.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mishra, Tulika& Khullar, Madhu& Bhatia, Aruna. 2010. Anticancer Potential of Aqueous Ethanol Seed Extract of Ziziphus mauritiana against Cancer Cell Lines and Ehrlich Ascites Carcinoma. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-497036
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mishra, Tulika…[et al.]. Anticancer Potential of Aqueous Ethanol Seed Extract of Ziziphus mauritiana against Cancer Cell Lines and Ehrlich Ascites Carcinoma. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-497036
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mishra, Tulika& Khullar, Madhu& Bhatia, Aruna. Anticancer Potential of Aqueous Ethanol Seed Extract of Ziziphus mauritiana against Cancer Cell Lines and Ehrlich Ascites Carcinoma. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-497036
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497036
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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