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Anticancer Potential of Aqueous Ethanol Seed Extract of Ziziphus mauritiana against Cancer Cell Lines and Ehrlich Ascites Carcinoma
Joint Authors
Mishra, Tulika
Bhatia, Aruna
Khullar, Madhu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ziziphus mauritiana (Lamk.) is a fruit tree that has folkloric implications against many ailments and diseases.
In the present study, anticancer potential of seed extract of Ziziphus mauritiana in vitro against different cell lines (HL-60, Molt-4, HeLa, and normal cell line HGF) by MTT assay as well as in vivo against Ehrich ascites carcinoma bearing Swiss albino mice was investigated.
The extract was found to markedly inhibit the proliferation of HL-60 cells.
Annexin and PI binding of treated HL-60 cells indicated apoptosis induction by extract in a dose-dependent manner.
The cell cycle analysis revealed a prominent increase in sub Go population at concentration of 20 μg/ml and above.
Agarose gel electrophoresis confirmed DNA fragmentation in HL-60 cells after 3 h incubation with extract.
The extract also exhibited potent anticancer potential in vivo.
Treatment of Ehrlich ascites carcinoma bearing Swiss albino mice with varied doses (100–800 mg/kg b.wt.) of plant extract significantly reduced tumor volume and viable tumor cell count and improved haemoglobin content, RBC count, mean survival time, tumor inhibition, and percentage life span.
The enhanced antioxidant status in extract-treated animals was evident from decline in levels of lipid peroxidation and increased levels of glutathione, catalase, and superoxide dismutase.
American Psychological Association (APA)
Mishra, Tulika& Khullar, Madhu& Bhatia, Aruna. 2010. Anticancer Potential of Aqueous Ethanol Seed Extract of Ziziphus mauritiana against Cancer Cell Lines and Ehrlich Ascites Carcinoma. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-497036
Modern Language Association (MLA)
Mishra, Tulika…[et al.]. Anticancer Potential of Aqueous Ethanol Seed Extract of Ziziphus mauritiana against Cancer Cell Lines and Ehrlich Ascites Carcinoma. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-497036
American Medical Association (AMA)
Mishra, Tulika& Khullar, Madhu& Bhatia, Aruna. Anticancer Potential of Aqueous Ethanol Seed Extract of Ziziphus mauritiana against Cancer Cell Lines and Ehrlich Ascites Carcinoma. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-497036
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497036