In Vitro and In Vivo Evaluation of Polyherbal Formulation against Russell’s Viper and Cobra Venom and Screening of Bioactive Components by Docking Studies
المؤلفون المشاركون
Rimal Isaac, R. S.
Nongalleima, Kh.
Deb, Lokesh
Dey, Amitabha
Chavali, Murthy
Singh, N. Surjit
Sakthivel, G.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The present study emphasizes to reveal the antivenom activity of Aristolochia bracteolata Lam., Tylophora indica (Burm.f.) Merrill, and Leucas aspera S.
which were evaluated against venoms of Daboia russelli russelli (Russell’s viper) and Naja naja (Indian cobra).
The aqueous extracts of leaves and roots of the above-mentioned plants and their polyherbal (1 : 1 : 1) formulation at a dose of 200 mg/kg showed protection against envenomed mice with LD50 doses of 0.44 mg/kg and 0.28 mg/kg against Russell’s viper and cobra venom, respectively.
In in vitro antioxidant activities sample extracts showed free radical scavenging effects in dose dependent manner.
Computational drug design and docking studies were carried out to predict the neutralizing principles of type I phospholipase A2 (PLA2) from Indian common krait venom.
This confirmed that aristolochic acid and leucasin can neutralize type I PLA2 enzyme.
Results suggest that these plants could serve as a source of natural antioxidants and common antidote for snake bite.
However, further studies are needed to identify the lead molecule responsible for antidote activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sakthivel, G.& Dey, Amitabha& Nongalleima, Kh.& Chavali, Murthy& Rimal Isaac, R. S.& Singh, N. Surjit…[et al.]. 2013. In Vitro and In Vivo Evaluation of Polyherbal Formulation against Russell’s Viper and Cobra Venom and Screening of Bioactive Components by Docking Studies. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-497480
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sakthivel, G.…[et al.]. In Vitro and In Vivo Evaluation of Polyherbal Formulation against Russell’s Viper and Cobra Venom and Screening of Bioactive Components by Docking Studies. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-497480
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sakthivel, G.& Dey, Amitabha& Nongalleima, Kh.& Chavali, Murthy& Rimal Isaac, R. S.& Singh, N. Surjit…[et al.]. In Vitro and In Vivo Evaluation of Polyherbal Formulation against Russell’s Viper and Cobra Venom and Screening of Bioactive Components by Docking Studies. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-497480
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497480
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر