In Vitro and In Vivo Evaluation of Polyherbal Formulation against Russell’s Viper and Cobra Venom and Screening of Bioactive Components by Docking Studies
Joint Authors
Rimal Isaac, R. S.
Nongalleima, Kh.
Deb, Lokesh
Dey, Amitabha
Chavali, Murthy
Singh, N. Surjit
Sakthivel, G.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The present study emphasizes to reveal the antivenom activity of Aristolochia bracteolata Lam., Tylophora indica (Burm.f.) Merrill, and Leucas aspera S.
which were evaluated against venoms of Daboia russelli russelli (Russell’s viper) and Naja naja (Indian cobra).
The aqueous extracts of leaves and roots of the above-mentioned plants and their polyherbal (1 : 1 : 1) formulation at a dose of 200 mg/kg showed protection against envenomed mice with LD50 doses of 0.44 mg/kg and 0.28 mg/kg against Russell’s viper and cobra venom, respectively.
In in vitro antioxidant activities sample extracts showed free radical scavenging effects in dose dependent manner.
Computational drug design and docking studies were carried out to predict the neutralizing principles of type I phospholipase A2 (PLA2) from Indian common krait venom.
This confirmed that aristolochic acid and leucasin can neutralize type I PLA2 enzyme.
Results suggest that these plants could serve as a source of natural antioxidants and common antidote for snake bite.
However, further studies are needed to identify the lead molecule responsible for antidote activity.
American Psychological Association (APA)
Sakthivel, G.& Dey, Amitabha& Nongalleima, Kh.& Chavali, Murthy& Rimal Isaac, R. S.& Singh, N. Surjit…[et al.]. 2013. In Vitro and In Vivo Evaluation of Polyherbal Formulation against Russell’s Viper and Cobra Venom and Screening of Bioactive Components by Docking Studies. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-497480
Modern Language Association (MLA)
Sakthivel, G.…[et al.]. In Vitro and In Vivo Evaluation of Polyherbal Formulation against Russell’s Viper and Cobra Venom and Screening of Bioactive Components by Docking Studies. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-497480
American Medical Association (AMA)
Sakthivel, G.& Dey, Amitabha& Nongalleima, Kh.& Chavali, Murthy& Rimal Isaac, R. S.& Singh, N. Surjit…[et al.]. In Vitro and In Vivo Evaluation of Polyherbal Formulation against Russell’s Viper and Cobra Venom and Screening of Bioactive Components by Docking Studies. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-497480
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497480