Effects of Three Different Fibrates on Intrahepatic Cholestasis Experimentally Induced in Rats
المؤلفون المشاركون
Hegazy, Sahar
El-Sisi, Alaa
El-Khateeb, Eman
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Background.
Activation of PPARα modulates cholesterol metabolism and suppresses bile acid synthesis.
This study aims to evaluate the effect of PPARα agonists, fenofibrate, bezafibrate, and gemfibrozil, on acute cholestasis induced by ethinylestradiol (EE) plus chlorpromazine (CPZ) in rats.
Method.
100 male albino rats (150–200 gm) were divided randomly into 10 equal groups.
Control group received 1% methylcellulose vehicle; disease group received CPZ plus EE for 5 consecutive days; four groups received either ursodeoxycholic acid, fenofibrate, bezafibrate, or gemfibrozil for 7 days; 2 days before EE + CPZ, three other groups received one of the three fibrates after GW6471, a selective PPARα antagonist in addition to EE + CPZ.
The final group received GW6471 alone.
Results.
The three fibrates showed marked reduction (P<0.05) in serum levels of ALP, GGT, ALT, AST, total bile acids, bilirubin, TNFα, and IL-1β and in hepatic malondialdehyde level as well as a significant increase in bile flow rate (P<0.05) in addition to improvements in histopathological parameters compared to diseased group.
In groups which received GW6471, these effects were completely abolished with fenofibrate and partially blocked with bezafibrate and gemfibrozil.
Conclusion.
Short-term administration of fibrates to EE/CPZ-induced intrahepatic cholestatic rats exerted beneficial effects on hepatocellular damage and apoptosis.
Fenofibrate anticholestatic effect was solely PPARα dependent while other mechanisms played part in bezafibrate and gemfibrozil actions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
El-Sisi, Alaa& Hegazy, Sahar& El-Khateeb, Eman. 2013. Effects of Three Different Fibrates on Intrahepatic Cholestasis Experimentally Induced in Rats. PPAR Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-497495
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
El-Sisi, Alaa…[et al.]. Effects of Three Different Fibrates on Intrahepatic Cholestasis Experimentally Induced in Rats. PPAR Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-497495
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
El-Sisi, Alaa& Hegazy, Sahar& El-Khateeb, Eman. Effects of Three Different Fibrates on Intrahepatic Cholestasis Experimentally Induced in Rats. PPAR Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-497495
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497495
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر