Effects of Three Different Fibrates on Intrahepatic Cholestasis Experimentally Induced in Rats
Joint Authors
Hegazy, Sahar
El-Sisi, Alaa
El-Khateeb, Eman
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Background.
Activation of PPARα modulates cholesterol metabolism and suppresses bile acid synthesis.
This study aims to evaluate the effect of PPARα agonists, fenofibrate, bezafibrate, and gemfibrozil, on acute cholestasis induced by ethinylestradiol (EE) plus chlorpromazine (CPZ) in rats.
Method.
100 male albino rats (150–200 gm) were divided randomly into 10 equal groups.
Control group received 1% methylcellulose vehicle; disease group received CPZ plus EE for 5 consecutive days; four groups received either ursodeoxycholic acid, fenofibrate, bezafibrate, or gemfibrozil for 7 days; 2 days before EE + CPZ, three other groups received one of the three fibrates after GW6471, a selective PPARα antagonist in addition to EE + CPZ.
The final group received GW6471 alone.
Results.
The three fibrates showed marked reduction (P<0.05) in serum levels of ALP, GGT, ALT, AST, total bile acids, bilirubin, TNFα, and IL-1β and in hepatic malondialdehyde level as well as a significant increase in bile flow rate (P<0.05) in addition to improvements in histopathological parameters compared to diseased group.
In groups which received GW6471, these effects were completely abolished with fenofibrate and partially blocked with bezafibrate and gemfibrozil.
Conclusion.
Short-term administration of fibrates to EE/CPZ-induced intrahepatic cholestatic rats exerted beneficial effects on hepatocellular damage and apoptosis.
Fenofibrate anticholestatic effect was solely PPARα dependent while other mechanisms played part in bezafibrate and gemfibrozil actions.
American Psychological Association (APA)
El-Sisi, Alaa& Hegazy, Sahar& El-Khateeb, Eman. 2013. Effects of Three Different Fibrates on Intrahepatic Cholestasis Experimentally Induced in Rats. PPAR Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-497495
Modern Language Association (MLA)
El-Sisi, Alaa…[et al.]. Effects of Three Different Fibrates on Intrahepatic Cholestasis Experimentally Induced in Rats. PPAR Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-497495
American Medical Association (AMA)
El-Sisi, Alaa& Hegazy, Sahar& El-Khateeb, Eman. Effects of Three Different Fibrates on Intrahepatic Cholestasis Experimentally Induced in Rats. PPAR Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-497495
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497495