Angiogenin Expression during Early Human Placental Development; Association with Blood Vessel Formation
المؤلفون المشاركون
Degrelle, Séverine A.
Guibourdenche, Jean
Pavlov, Nadine
Evain-Brion, Danièle
Frendo, Jean-Louis
Badet, Josette
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-01
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
The placenta is a transient organ essential for fetal development.
During human placental development, chorionic villi grow in coordination with a large capillary network resulting from both vasculogenesis and angiogenesis.
Angiogenin is one of the most potent inducers of neovascularisation in experimental models in vivo.
We and others have previously mapped angiogenin expression in the human term placenta.
Here, we explored angiogenin involvement in early human placental development.
We studied, angiogenin expression by in situ hybridisation and/or by RT-PCR in tissues and primary cultured trophoblastic cells and angiogenin cellular distribution by coimmunolabelling with cell markers: CD31 (PECAM-1), vascular endothelial cadherin (VE-cadherin), vascular endothelial growth factor receptor-2 (VEGF-R2), Tie-2, von Willebrand factor, CD34, erythropoeitin receptor (Epo-R), alpha-smooth muscle actin, CD45, cytokeratin 7, and Ki-67.
Extravillous and villous cytotrophoblasts, isolated and differentiated in vitro, expressed and secreted angiogenin.
Angiogenin was detected in villous trophoblastic layers, and structured and nascent fetal vessels.
In decidua, it was expressed by glandular epithelial cells, vascular cells and macrophages.
The observed pattern of angiogenin expression is compatible with a role in blood vessel formation and in cross-talk between trophoblasts and endothelial cells.
In view of angiogenin properties, we suggest that angiogenin may participate in placental vasculogenesis and organogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pavlov, Nadine& Frendo, Jean-Louis& Guibourdenche, Jean& Degrelle, Séverine A.& Evain-Brion, Danièle& Badet, Josette. 2014. Angiogenin Expression during Early Human Placental Development; Association with Blood Vessel Formation. BioMed Research International،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-497529
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pavlov, Nadine…[et al.]. Angiogenin Expression during Early Human Placental Development; Association with Blood Vessel Formation. BioMed Research International No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-497529
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pavlov, Nadine& Frendo, Jean-Louis& Guibourdenche, Jean& Degrelle, Séverine A.& Evain-Brion, Danièle& Badet, Josette. Angiogenin Expression during Early Human Placental Development; Association with Blood Vessel Formation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-497529
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497529
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر