Angiogenin Expression during Early Human Placental Development; Association with Blood Vessel Formation
Joint Authors
Degrelle, Séverine A.
Guibourdenche, Jean
Pavlov, Nadine
Evain-Brion, Danièle
Frendo, Jean-Louis
Badet, Josette
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The placenta is a transient organ essential for fetal development.
During human placental development, chorionic villi grow in coordination with a large capillary network resulting from both vasculogenesis and angiogenesis.
Angiogenin is one of the most potent inducers of neovascularisation in experimental models in vivo.
We and others have previously mapped angiogenin expression in the human term placenta.
Here, we explored angiogenin involvement in early human placental development.
We studied, angiogenin expression by in situ hybridisation and/or by RT-PCR in tissues and primary cultured trophoblastic cells and angiogenin cellular distribution by coimmunolabelling with cell markers: CD31 (PECAM-1), vascular endothelial cadherin (VE-cadherin), vascular endothelial growth factor receptor-2 (VEGF-R2), Tie-2, von Willebrand factor, CD34, erythropoeitin receptor (Epo-R), alpha-smooth muscle actin, CD45, cytokeratin 7, and Ki-67.
Extravillous and villous cytotrophoblasts, isolated and differentiated in vitro, expressed and secreted angiogenin.
Angiogenin was detected in villous trophoblastic layers, and structured and nascent fetal vessels.
In decidua, it was expressed by glandular epithelial cells, vascular cells and macrophages.
The observed pattern of angiogenin expression is compatible with a role in blood vessel formation and in cross-talk between trophoblasts and endothelial cells.
In view of angiogenin properties, we suggest that angiogenin may participate in placental vasculogenesis and organogenesis.
American Psychological Association (APA)
Pavlov, Nadine& Frendo, Jean-Louis& Guibourdenche, Jean& Degrelle, Séverine A.& Evain-Brion, Danièle& Badet, Josette. 2014. Angiogenin Expression during Early Human Placental Development; Association with Blood Vessel Formation. BioMed Research International،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-497529
Modern Language Association (MLA)
Pavlov, Nadine…[et al.]. Angiogenin Expression during Early Human Placental Development; Association with Blood Vessel Formation. BioMed Research International No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-497529
American Medical Association (AMA)
Pavlov, Nadine& Frendo, Jean-Louis& Guibourdenche, Jean& Degrelle, Séverine A.& Evain-Brion, Danièle& Badet, Josette. Angiogenin Expression during Early Human Placental Development; Association with Blood Vessel Formation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-497529
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497529