Expression of Potential Cancer Stem Cell Marker ABCG2 is Associated with Malignant Behaviors of Hepatocellular Carcinoma
المؤلفون المشاركون
Jiao, Hongbo
Jiang, Chunping
Luo, Weihuan
Wang, Zhongxia
Zhang, Guang
Wu, Junhua
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Despite improvement in treatment, the prognosis of hepatocellular carcinoma (HCC) remains disastrous.
Cancer stem cells (CSCs) may be responsible for cancer malignant behaviors.
ATP-binding cassette, subfamily G, member 2 (ABCG2) is widely expressed in both normal and cancer stem cells and may play an important role in cancer malignant behaviors.
Methods.
The expression of ABCG2 in HCC tissues and SMMC-7721 cells was examined, and the relevance of ABCG2 expression with clinical characteristics was analyzed.
ABCG2+ and ABCG2− cells were sorted, and the potential of tumorigenicity was determined.
Expression level of ABCG2 was manipulated by RNA interference and overexpression.
Malignant behaviors including proliferation, drug resistance, migration, and invasion were studied in vitro.
Results.
Expression of ABCG2 was found in a minor group of cells in HCC tissues and cell lines.
ABCG2 expression showed tendencies of association with unfavorable prognosis factors.
ABCG2 positive cells showed a superior tumorigenicity.
Upregulation of ABCG2 enhanced the capacity of proliferation, doxorubicin resistance, migration, and invasion potential, while downregulation of ABCG2 significantly decreased these malignant behaviors.
Conclusion.
Our results indicate that ABCG2 is a potential CSC marker for HCC.
Its expression level has a close relationship with tumorigenicity, proliferation, drug resistance, and metastasis ability.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Guang& Wang, Zhongxia& Luo, Weihuan& Jiao, Hongbo& Wu, Junhua& Jiang, Chunping. 2013. Expression of Potential Cancer Stem Cell Marker ABCG2 is Associated with Malignant Behaviors of Hepatocellular Carcinoma. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-497639
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Guang…[et al.]. Expression of Potential Cancer Stem Cell Marker ABCG2 is Associated with Malignant Behaviors of Hepatocellular Carcinoma. Gastroenterology Research and Practice No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-497639
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Guang& Wang, Zhongxia& Luo, Weihuan& Jiao, Hongbo& Wu, Junhua& Jiang, Chunping. Expression of Potential Cancer Stem Cell Marker ABCG2 is Associated with Malignant Behaviors of Hepatocellular Carcinoma. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-497639
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497639
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر