Expression of Potential Cancer Stem Cell Marker ABCG2 is Associated with Malignant Behaviors of Hepatocellular Carcinoma
Joint Authors
Jiao, Hongbo
Jiang, Chunping
Luo, Weihuan
Wang, Zhongxia
Zhang, Guang
Wu, Junhua
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Despite improvement in treatment, the prognosis of hepatocellular carcinoma (HCC) remains disastrous.
Cancer stem cells (CSCs) may be responsible for cancer malignant behaviors.
ATP-binding cassette, subfamily G, member 2 (ABCG2) is widely expressed in both normal and cancer stem cells and may play an important role in cancer malignant behaviors.
Methods.
The expression of ABCG2 in HCC tissues and SMMC-7721 cells was examined, and the relevance of ABCG2 expression with clinical characteristics was analyzed.
ABCG2+ and ABCG2− cells were sorted, and the potential of tumorigenicity was determined.
Expression level of ABCG2 was manipulated by RNA interference and overexpression.
Malignant behaviors including proliferation, drug resistance, migration, and invasion were studied in vitro.
Results.
Expression of ABCG2 was found in a minor group of cells in HCC tissues and cell lines.
ABCG2 expression showed tendencies of association with unfavorable prognosis factors.
ABCG2 positive cells showed a superior tumorigenicity.
Upregulation of ABCG2 enhanced the capacity of proliferation, doxorubicin resistance, migration, and invasion potential, while downregulation of ABCG2 significantly decreased these malignant behaviors.
Conclusion.
Our results indicate that ABCG2 is a potential CSC marker for HCC.
Its expression level has a close relationship with tumorigenicity, proliferation, drug resistance, and metastasis ability.
American Psychological Association (APA)
Zhang, Guang& Wang, Zhongxia& Luo, Weihuan& Jiao, Hongbo& Wu, Junhua& Jiang, Chunping. 2013. Expression of Potential Cancer Stem Cell Marker ABCG2 is Associated with Malignant Behaviors of Hepatocellular Carcinoma. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-497639
Modern Language Association (MLA)
Zhang, Guang…[et al.]. Expression of Potential Cancer Stem Cell Marker ABCG2 is Associated with Malignant Behaviors of Hepatocellular Carcinoma. Gastroenterology Research and Practice No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-497639
American Medical Association (AMA)
Zhang, Guang& Wang, Zhongxia& Luo, Weihuan& Jiao, Hongbo& Wu, Junhua& Jiang, Chunping. Expression of Potential Cancer Stem Cell Marker ABCG2 is Associated with Malignant Behaviors of Hepatocellular Carcinoma. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-497639
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497639