Evaluation of In Vitro Uterotonic Activities of Fruit Extracts of Ficus asperifolia in Rats
المؤلفون المشاركون
Benoît Nguelefack, Telesphore
Watcho, Pierre
Kamanyi, Albert
Ngadjui, Esther
Alango Nkeng-Efouet, Pepin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The aim of the present study was to determine the uterotonic activities of Ficus asperifolia and investigate its mechanism.
The effects of aqueous and methanol extracts of the dried fruits of F.
asperifolia (0.05–1.60 mg mL−1) were evaluated on estrogenized isolated rat uterus in the presence and absence of atropine (1.73–55.27 nM), pyrilamine maleate (1.25 × 10−3 to 40 × 10−3 M), indomethacin (0.06 × 10−5 to 2.00 × 10−5 M) or hexamethonium (0.66 × 10−4 to 21.43 × 10−4 M).
Aqueous (EC50, 0.36 mg mL−1) and methanol (EC50, 0.22 mg mL−1) extracts as well as oxytocin (EC50, 0.02 nM), acetylcholine (EC50, 7.87 nM) and histamine (EC50, 0.76 nM) evoked concentration-dependent contractions of the uterus.
Atropine, pyrilamine maleate and indomethacin concentration dependently blocked the response of the uterus to acetylcholine (IC50, 4.82 nM), histamine (IC50, 2.49 nM) and oxytocin (IC50, 0.07 nM), respectively, and to aqueous extract.
Hexamethonium produced graded decreases in oxytocin-induced uterine contractions (IC50, 0.37 μM), but did not prevent the contractile effects of the aqueous extract (IC50, 9.88 μM).
These results suggest that F.
asperifolia-induced uterotonic effect is related to the release of prostaglandins and contraction of the myometrial cells through muscarinic, oxytocic and H1 histamine receptors.
These data further give added value to the ethnic use of F.
asperifolia for its abortificient and contraceptive properties.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Watcho, Pierre& Ngadjui, Esther& Alango Nkeng-Efouet, Pepin& Benoît Nguelefack, Telesphore& Kamanyi, Albert. 2011. Evaluation of In Vitro Uterotonic Activities of Fruit Extracts of Ficus asperifolia in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-497721
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Watcho, Pierre…[et al.]. Evaluation of In Vitro Uterotonic Activities of Fruit Extracts of Ficus asperifolia in Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-497721
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Watcho, Pierre& Ngadjui, Esther& Alango Nkeng-Efouet, Pepin& Benoît Nguelefack, Telesphore& Kamanyi, Albert. Evaluation of In Vitro Uterotonic Activities of Fruit Extracts of Ficus asperifolia in Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-497721
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497721
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر