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Evaluation of In Vitro Uterotonic Activities of Fruit Extracts of Ficus asperifolia in Rats
Joint Authors
Benoît Nguelefack, Telesphore
Watcho, Pierre
Kamanyi, Albert
Ngadjui, Esther
Alango Nkeng-Efouet, Pepin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of the present study was to determine the uterotonic activities of Ficus asperifolia and investigate its mechanism.
The effects of aqueous and methanol extracts of the dried fruits of F.
asperifolia (0.05–1.60 mg mL−1) were evaluated on estrogenized isolated rat uterus in the presence and absence of atropine (1.73–55.27 nM), pyrilamine maleate (1.25 × 10−3 to 40 × 10−3 M), indomethacin (0.06 × 10−5 to 2.00 × 10−5 M) or hexamethonium (0.66 × 10−4 to 21.43 × 10−4 M).
Aqueous (EC50, 0.36 mg mL−1) and methanol (EC50, 0.22 mg mL−1) extracts as well as oxytocin (EC50, 0.02 nM), acetylcholine (EC50, 7.87 nM) and histamine (EC50, 0.76 nM) evoked concentration-dependent contractions of the uterus.
Atropine, pyrilamine maleate and indomethacin concentration dependently blocked the response of the uterus to acetylcholine (IC50, 4.82 nM), histamine (IC50, 2.49 nM) and oxytocin (IC50, 0.07 nM), respectively, and to aqueous extract.
Hexamethonium produced graded decreases in oxytocin-induced uterine contractions (IC50, 0.37 μM), but did not prevent the contractile effects of the aqueous extract (IC50, 9.88 μM).
These results suggest that F.
asperifolia-induced uterotonic effect is related to the release of prostaglandins and contraction of the myometrial cells through muscarinic, oxytocic and H1 histamine receptors.
These data further give added value to the ethnic use of F.
asperifolia for its abortificient and contraceptive properties.
American Psychological Association (APA)
Watcho, Pierre& Ngadjui, Esther& Alango Nkeng-Efouet, Pepin& Benoît Nguelefack, Telesphore& Kamanyi, Albert. 2011. Evaluation of In Vitro Uterotonic Activities of Fruit Extracts of Ficus asperifolia in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-497721
Modern Language Association (MLA)
Watcho, Pierre…[et al.]. Evaluation of In Vitro Uterotonic Activities of Fruit Extracts of Ficus asperifolia in Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-497721
American Medical Association (AMA)
Watcho, Pierre& Ngadjui, Esther& Alango Nkeng-Efouet, Pepin& Benoît Nguelefack, Telesphore& Kamanyi, Albert. Evaluation of In Vitro Uterotonic Activities of Fruit Extracts of Ficus asperifolia in Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-497721
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497721