Effects of a Preconditioning Oral Nutritional Supplement on Pig Livers after Warm Ischemia
المؤلفون المشاركون
Schemmer, Peter
Schneider, Heinz
Yi, Xue
Mohr, Elvira
Liang, Rui
Büchler, Markus W.
Mikalauskas, Saulius
Gross, Marie-Luise
Benzing, Steffen
Zorn, Markus
Li, Zhanqing
Nickkholgh, Arash
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-25
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Several approaches have been proposed to pharmacologically ameliorate hepatic ischemia/reperfusion injury (IRI).
This study was designed to evaluate the effects of a preconditioning oral nutritional supplement (pONS) containing glutamine, antioxidants, and green tea extract on hepatic warm IRI in pigs.
Methods.
pONS (70 g per serving, Fresenius Kabi, Germany) was dissolved in 250 mL tap water and given to pigs 24, 12, and 2 hrs before warm ischemia of the liver.
A fourth dose was given 3 hrs after reperfusion.
Controls were given the same amount of cellulose with the same volume of water.
Two hours after the third dose of pONS, both the portal vein and the hepatic artery were clamped for 40 min.
0.5, 3, 6, and 8 hrs after reperfusion, heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), portal venous flow (PVF), hepatic arterial flow (HAF), bile flow, and transaminases were measured.
Liver tissue was taken 8 hrs after reperfusion for histology and immunohistochemistry.
Results.
HR, MAP, CVP, HAF, and PVF were comparable between the two groups.
pONS significantly increased bile flow 8 hrs after reperfusion.
ALT and AST were significantly lower after pONS.
Histology showed significantly more severe necrosis and neutrophil infiltration in controls.
pONS significantly decreased the index of immunohistochemical expression for TNF-α, MPO, and cleaved caspase-3 (P<0.001).
Conclusion.
Administration of pONS before and after tissue damage protects the liver from warm IRI via mechanisms including decreasing oxidative stress, lipid peroxidation, apoptosis, and necrosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nickkholgh, Arash& Li, Zhanqing& Yi, Xue& Mohr, Elvira& Liang, Rui& Mikalauskas, Saulius…[et al.]. 2012. Effects of a Preconditioning Oral Nutritional Supplement on Pig Livers after Warm Ischemia. HPB Surgery،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-497725
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nickkholgh, Arash…[et al.]. Effects of a Preconditioning Oral Nutritional Supplement on Pig Livers after Warm Ischemia. HPB Surgery No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-497725
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nickkholgh, Arash& Li, Zhanqing& Yi, Xue& Mohr, Elvira& Liang, Rui& Mikalauskas, Saulius…[et al.]. Effects of a Preconditioning Oral Nutritional Supplement on Pig Livers after Warm Ischemia. HPB Surgery. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-497725
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497725
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر