Immune Activation and Inflammation in Patients with Cardiovascular Disease Are Associated with Higher Phenylalanine to Tyrosine Ratios : The Ludwigshafen Risk and Cardiovascular Health Study
المؤلفون المشاركون
Meinitzer, Andreas
Grammer, Tanja B.
Kleber, Marcus E.
Fuchs, Dietmar
Murr, Christian
März, Winfried
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-10
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Higher serum neopterin is associated with increased mortality in patients with coronary artery disease (CAD).
Preferentially Th1-type cytokine interferon-γ stimulates neopterin production by GTP cychlohydrolase I (GCH-I) in parallel in monocyte-derived macrophages and dendritic cells.
In other cells, activation of GCH-I leads to the formation of 5,6,7,8-tetrahydrobiopterin (BH4), the necessary cofactor of amino acid hydroxylases like phenylalanine 4-hydroxylase (PAH).
Serum concentrations of phenylalanine, tyrosine, neopterin, and high sensitivity C-reactive protein (hsCRP) were measured in 1196 patients derived from the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study, a cohort study among patients referred for coronary angiography.
The phenylalanine to tyrosine ratio (Phe/Tyr) served as an estimate of phenylalanine hydroxylase (PAH) enzyme activity.
Serum concentrations of phenylalanine and tyrosine and of Phe/Tyr did not differ between individuals with or without CAD (Welch's t-test: P = n.s.).
Higher neopterin and hsCRP concentrations were observed in CAD patients compared to controls (P<0.0001) and they correlated with Phe/Tyr (Spearman's rank correlation for neopterin: rs = 0.216 and hsCRP: rs = 0.122; both of P<0.0001) concentrations.
In conclusion, immune activation is associated with higher Phe/Tyr in CAD patients.
Data indicates subnormal PAH activity which might be involved in the precipitation of neuropsychiatric symptoms in patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Murr, Christian& Grammer, Tanja B.& Meinitzer, Andreas& Kleber, Marcus E.& März, Winfried& Fuchs, Dietmar. 2014. Immune Activation and Inflammation in Patients with Cardiovascular Disease Are Associated with Higher Phenylalanine to Tyrosine Ratios : The Ludwigshafen Risk and Cardiovascular Health Study. Journal of Amino Acids،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-497749
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Murr, Christian…[et al.]. Immune Activation and Inflammation in Patients with Cardiovascular Disease Are Associated with Higher Phenylalanine to Tyrosine Ratios : The Ludwigshafen Risk and Cardiovascular Health Study. Journal of Amino Acids No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-497749
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Murr, Christian& Grammer, Tanja B.& Meinitzer, Andreas& Kleber, Marcus E.& März, Winfried& Fuchs, Dietmar. Immune Activation and Inflammation in Patients with Cardiovascular Disease Are Associated with Higher Phenylalanine to Tyrosine Ratios : The Ludwigshafen Risk and Cardiovascular Health Study. Journal of Amino Acids. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-497749
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497749
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر