Immune Activation and Inflammation in Patients with Cardiovascular Disease Are Associated with Higher Phenylalanine to Tyrosine Ratios : The Ludwigshafen Risk and Cardiovascular Health Study
Joint Authors
Meinitzer, Andreas
Grammer, Tanja B.
Kleber, Marcus E.
Fuchs, Dietmar
Murr, Christian
März, Winfried
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Higher serum neopterin is associated with increased mortality in patients with coronary artery disease (CAD).
Preferentially Th1-type cytokine interferon-γ stimulates neopterin production by GTP cychlohydrolase I (GCH-I) in parallel in monocyte-derived macrophages and dendritic cells.
In other cells, activation of GCH-I leads to the formation of 5,6,7,8-tetrahydrobiopterin (BH4), the necessary cofactor of amino acid hydroxylases like phenylalanine 4-hydroxylase (PAH).
Serum concentrations of phenylalanine, tyrosine, neopterin, and high sensitivity C-reactive protein (hsCRP) were measured in 1196 patients derived from the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study, a cohort study among patients referred for coronary angiography.
The phenylalanine to tyrosine ratio (Phe/Tyr) served as an estimate of phenylalanine hydroxylase (PAH) enzyme activity.
Serum concentrations of phenylalanine and tyrosine and of Phe/Tyr did not differ between individuals with or without CAD (Welch's t-test: P = n.s.).
Higher neopterin and hsCRP concentrations were observed in CAD patients compared to controls (P<0.0001) and they correlated with Phe/Tyr (Spearman's rank correlation for neopterin: rs = 0.216 and hsCRP: rs = 0.122; both of P<0.0001) concentrations.
In conclusion, immune activation is associated with higher Phe/Tyr in CAD patients.
Data indicates subnormal PAH activity which might be involved in the precipitation of neuropsychiatric symptoms in patients.
American Psychological Association (APA)
Murr, Christian& Grammer, Tanja B.& Meinitzer, Andreas& Kleber, Marcus E.& März, Winfried& Fuchs, Dietmar. 2014. Immune Activation and Inflammation in Patients with Cardiovascular Disease Are Associated with Higher Phenylalanine to Tyrosine Ratios : The Ludwigshafen Risk and Cardiovascular Health Study. Journal of Amino Acids،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-497749
Modern Language Association (MLA)
Murr, Christian…[et al.]. Immune Activation and Inflammation in Patients with Cardiovascular Disease Are Associated with Higher Phenylalanine to Tyrosine Ratios : The Ludwigshafen Risk and Cardiovascular Health Study. Journal of Amino Acids No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-497749
American Medical Association (AMA)
Murr, Christian& Grammer, Tanja B.& Meinitzer, Andreas& Kleber, Marcus E.& März, Winfried& Fuchs, Dietmar. Immune Activation and Inflammation in Patients with Cardiovascular Disease Are Associated with Higher Phenylalanine to Tyrosine Ratios : The Ludwigshafen Risk and Cardiovascular Health Study. Journal of Amino Acids. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-497749
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497749