Therapeutic Potential of Polar and Non-Polar Extracts of Cyanthillium cinereum In Vitro
المؤلفون المشاركون
Mathew, Lazar
Rajkumar, V.
Guha, Gunjan
Ashok Kumar, Rangasamy
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Cyanthillium cinereum (Less.) H.
Rob.
(Asteraceae) has been traditionally known for its medicinal properties, all aspects of which are yet to be exploited.
This study was aimed at investigating the therapeutic potential of polar (methanolic and aqueous) and nonpolar (hexane and chloroform) crude extracts of the whole plant.
Several parameters including free-radical (DPPH•, ABTS•+, H2O2 and •OH) scavenging, reducing power, protection of DNA against oxidative damage, cytotoxicity, inhibition of oxidative hemolysis in erythrocytes, total phenolic content and inhibition of lipid peroxidation were examined.
All the free-radical generating assay models demonstrated positive scavenging efficiency with differential but considerable magnitudes for the four extracts.
However, only the hexane extract showed significant H2O2 scavenging effect.
Lipid peroxidation was estimated by thiobarbituric acid-malondialdehyde (MDA) reaction, and a high degree of inhibition was shown by all the extracts.
Reducing power of the polar extracts was higher than the non-polar ones.
All extracts showed a concentration-dependent increase in phenolic contents.
Oxidative damage to erythrocytes was hindered by all extracts in diverse degrees.
XTT assay showed that all extracts have mild cytotoxic property.
The aqueous extract evidently demonstrated protective effect on pBR322 plasmid DNA against oxidative breakdown.
These results suggested the potential of C.
cinereum as medicine against free-radical-associated oxidative damage and related degenerative diseases involving metabolic stress, genotoxicity and cytotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guha, Gunjan& Rajkumar, V.& Ashok Kumar, Rangasamy& Mathew, Lazar. 2011. Therapeutic Potential of Polar and Non-Polar Extracts of Cyanthillium cinereum In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-497861
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guha, Gunjan…[et al.]. Therapeutic Potential of Polar and Non-Polar Extracts of Cyanthillium cinereum In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-497861
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guha, Gunjan& Rajkumar, V.& Ashok Kumar, Rangasamy& Mathew, Lazar. Therapeutic Potential of Polar and Non-Polar Extracts of Cyanthillium cinereum In Vitro. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-497861
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497861
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر