Therapeutic Potential of Polar and Non-Polar Extracts of Cyanthillium cinereum In Vitro
Joint Authors
Mathew, Lazar
Rajkumar, V.
Guha, Gunjan
Ashok Kumar, Rangasamy
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cyanthillium cinereum (Less.) H.
Rob.
(Asteraceae) has been traditionally known for its medicinal properties, all aspects of which are yet to be exploited.
This study was aimed at investigating the therapeutic potential of polar (methanolic and aqueous) and nonpolar (hexane and chloroform) crude extracts of the whole plant.
Several parameters including free-radical (DPPH•, ABTS•+, H2O2 and •OH) scavenging, reducing power, protection of DNA against oxidative damage, cytotoxicity, inhibition of oxidative hemolysis in erythrocytes, total phenolic content and inhibition of lipid peroxidation were examined.
All the free-radical generating assay models demonstrated positive scavenging efficiency with differential but considerable magnitudes for the four extracts.
However, only the hexane extract showed significant H2O2 scavenging effect.
Lipid peroxidation was estimated by thiobarbituric acid-malondialdehyde (MDA) reaction, and a high degree of inhibition was shown by all the extracts.
Reducing power of the polar extracts was higher than the non-polar ones.
All extracts showed a concentration-dependent increase in phenolic contents.
Oxidative damage to erythrocytes was hindered by all extracts in diverse degrees.
XTT assay showed that all extracts have mild cytotoxic property.
The aqueous extract evidently demonstrated protective effect on pBR322 plasmid DNA against oxidative breakdown.
These results suggested the potential of C.
cinereum as medicine against free-radical-associated oxidative damage and related degenerative diseases involving metabolic stress, genotoxicity and cytotoxicity.
American Psychological Association (APA)
Guha, Gunjan& Rajkumar, V.& Ashok Kumar, Rangasamy& Mathew, Lazar. 2011. Therapeutic Potential of Polar and Non-Polar Extracts of Cyanthillium cinereum In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-497861
Modern Language Association (MLA)
Guha, Gunjan…[et al.]. Therapeutic Potential of Polar and Non-Polar Extracts of Cyanthillium cinereum In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-497861
American Medical Association (AMA)
Guha, Gunjan& Rajkumar, V.& Ashok Kumar, Rangasamy& Mathew, Lazar. Therapeutic Potential of Polar and Non-Polar Extracts of Cyanthillium cinereum In Vitro. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-497861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497861